نتایج جستجو برای: quinolinic acid
تعداد نتایج: 747454 فیلتر نتایج به سال:
Dose-response curves for activation of excitatory amino acid receptors on mouse embryonic hippocampal neurons in culture were recorded for 15 excitatory amino acids, including the L-isomers of glutamate, aspartate, and a family of endogenous sulfur amino acids. In the presence of 3 microM glycine, with no extracellular Mg, micromolar concentrations of 11 of these amino acids produced selective ...
Central nervous system infection of neonatal and adult rats with Borna disease virus (BDV) results in neuronal destruction and behavioral abnormalities with differential immune-mediated involvement. Neuroactive metabolites generated from the kynurenine pathway of tryptophan degradation have been implicated in several human neurodegenerative disorders. Here, we report that brain expression of ke...
To assess the neurotoxic properties of the glutamate agonist quisqualic acid (QA) in immature brain, we injected this compound (100 nmol QA/1 microliter) directly into the striatum of 7-day-old rats. QA produced neuronal necrosis and glial infiltration in 14 pups and reduced the size of the striatum and hippocampus on the side of injection. Intracerebral injection of QA provides a new method fo...
BACKGROUND Neuroinflammatory processes are increasingly believed to participate in the pathophysiology of a number of major psychiatric diseases, including depression. Immune activation stimulates the conversion of the amino acid tryptophan to kynurenine, leading to the formation of neuroactive metabolites, such as quinolinic acid and kynurenic acid. These compounds affect glutamatergic neurotr...
The oxidation of 3-hydroxyanthranilic acid, an intermediate in the conversion of tryptophan to niacin (l-3), is catalyzed by a liver oxidase (4). The first recognized product, termed Compound I (5), yields quinolinic acid spontaneously or picolinic acid under the influence of a liver carboxylase (6). The intermediate is detectable by its absorption maximum at 360 rnp (4). Wiss and Bettendorf (7...
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