In recent years the new technology of microarrays has made it feasible to measure expression of thousands of genes to identify changes between different biological states. In such biological experiments we are confronted with the problem of high-dimensionality because of thousands of genes involved and at the same time with small sample sizes (due to limited availability of cases). The set of d...

objective(s): the aim of this study was to investigate the methylation status and mrna expression levels of p15, death-associated protein kinase (dapk), and suppressor of cytokine signaling-1 (socs1) genes in multiple myeloma (mm). materials and methods: the bone marrow samples of 54 mm patients were collected and the methylation status of the p15, dapk, and socs1 gene promoter regions was dete...

Overlapping gene lists can reveal biological meanings and may lead to novel hypotheses. For example, histone modification is an important cellular mechanism that can pack and re-pack chromatin. By making the chromatin structure more dense or loose, the gene expression can be turned on or off. Tri-methylation on lysine 4 of histone H3 (H3K4me3) is associated with gene activation and its genome-w...

b a c k g r o u n d  & aim: it is very helpful to classify and predict the clinical  category  of a sample based  on  its  gene  expression  profile.  this  study  was  conducted  to predict  tissues  of colorectal adenoma,  adenocarcinoma,  and  paired  normal  in  colon  based  on  microarray  data  using  nearest shrunken centroid method. methods   &  materials:    in  this  study,   the  co...