Amino acid sequence information was obtained for the NH2 terminus, and for endogenous peptides generated by trypsin digestion, of a purified, truncated form of rat hepatic squalene synthase (RSS, EC 2.5.1.21) (Shechter, I., Klinger, E., Rucker, M. L., Engstrom, R. G., Spirito, J. A., Islam, M. A., Boettcher, B. R., and Weinstein, D. B. (1992) J. Biol. Chem. 267, 8628-8635). Degenerate primers, ...

We developed a Gene Annotation Easy Viewer (GAEV) that integrates the gene annotation data from the KEGG (Kyoto Encyclopedia of Genes and Genomes) Automatic Annotation Server. GAEV generates an easy-to-read table that summarizes the query gene name, the KO (KEGG Orthology) number, name of gene orthologs, functional definition of the ortholog, and the functional pathways that query gene has been...

BACKGROUND Tumor human papillomavirus (HPV) status is an important prognostic factor in locoregionally advanced squamous cell carcinoma of the head and neck (SCCHN). Prognostic value in recurrent and/or metastatic (R/M) disease remains to be confirmed. This retrospective analysis of the EXTREME trial, comparing chemotherapy plus cetuximab with chemotherapy first line in R/M SCCHN, investigated ...

Objective: to examine the relationship between BMI, self-esteem and quality of life among Saudi Adolescent females. Method: A descriptive correlational design was used. A convenience sample of 416 participants was included. An explanation about the purpose and the nature of the study was offered for each participant. Qualified subjects were asked to complete the survey questionnaire and get the...

BJECTIVES To determine the medium term efficacy and morbidity of patients who underwent cryoa as primary therapy for localized prostate cancer followed by a penile rehabilitation regim ETHODS Patients were treated with whole gland cryoablation. Those potent at intervention were e aged to use a vacuum erection device regularly after treatment. Incontinence was defined leakage of urine. Potency w...

This paper outlines a qualitative research investigation of intranets and their capacity to facilitate organizational knowledge work. The study calls for an alternate view to intranet systems development and evaluation, one that tempers a predominant focus on information content and technology concerns with an awareness of the information needs, uses, and contexts of organizational participants...

The interaction of lipoprotein lipase (LPL) with heparan sulfate proteoglycans plays an important role in the metabolism and catalytic function of the enzyme. We have used site-directed mutagenesis to replace the basic residues contained in a discontinuous charge cluster (residues Lys 321, Arg 405, Arg 407, Lys 409, Lys 415, and Lys 416) of avian LPL with asparagine. The mutant proteins were ex...

We present data on the stellar kinematics of the brightest ellipticals in HCG 62, HCG 68, NGC 2300 groups. Moreover, we report on ASCA GIS as well as optical observations of the early-type member of the pair K 416 (NGC 5480/5481) similar, in many respects, to the dominant pair in the NGC 2300 group. The kinematics of HCG 62a/b and HCG 68a/b indicate that they are not interacting pairs. HCG 62a ...

Src and Src-family protein-tyrosine kinases are regulatory proteins that play key roles in cell differentiation, motility, proliferation, and survival. The initially described phosphorylation sites of Src include an activating phosphotyrosine 416 that results from autophosphorylation, and an inhibiting phosphotyrosine 527 that results from phosphorylation by C-terminal Src kinase (Csk) and Csk ...