Mesenchymal stem cells (MSCs) are very attractive candidates in cell-based strategies that target inflammatory diseases. Preclinical animal studies and many clinical trials have demonstrated that human MSCs can be safely administered and that they modify the inflammatory process in the targeted injured tissue. Our laboratory developed a novel method that optimizes the anti-inflammatory effects ...

BACKGROUND Emerging research seeking novel analgesic drugs focuses on agents targeting group-II metabotropic glutamate receptors (mGlu2 and mGlu3 receptors). N-Acetylcysteine (NAC) enhances the endogenous activation of mGlu2/3 receptors by activating the glial glutamate:cystine membrane exchanger. Here, we examined whether NAC inhibits nociceptive responses in humans and animals. We tested the ...

Swertia chirata, a Gentian species, can be traced through the medicinal history as a nontoxic and safe ethnomedicinal herb and has been mentioned in medical papyri to expel fever, relieve headache, to draw out inflammation and to stimulate CNS. The ethanolic root extract of Swertia chirata was chosen for pharmacological screening and analgesic and anti-inflammatory activities in animal models. ...

Enhanced Heat Release Rate (HRR) methodology has been extended to the Mass Loss Calorimeter (MLC) and the Modified Schlyter flame spread test to evaluate fire retardant effectiveness used on wood based materials. Modifications to MLC include installation of thermopile on the chimney walls to correct systematic errors to the sensible HRR calculations to account for radiant energy losses to the c...

In the present experiments, we characterized the agonist and antagonist effects of butorphanol in mice. In the mouse radiant-heat tail-flick test, the mu agonists morphine and fentanyl and the kappa agonist U50,488H were fully effective as analgesics, whereas butorphanol was partially effective (producing 82% of maximal possible analgesic effect). Naltrexone was approximately equipotent in anta...

This involves having production units distribute to the consuming units through a single vertical and central distribution network. Each fl oor is served by an indirect connected substation (Figure 3). Enhancing comfort1 and reducing energy demand2 is possible when fl oorto-fl oor (rather than building-to-building) consumption is moderate (cooling) or low (heating) temperature radiant-based sur...

BACKGROUND Cissampelos pareira Linn. is considered as an established source of Patha, whereas Cyclea peltata (Lam.) Hook. F. & Thomas is used as a source plant of Patha in the southern part of India. In classical texts, two different varieties of Patha, i.e. Rajpatha (C. peltata) and Laghupatha (C. pareira), are mentioned which possess almost similar properties. OBJECTIVE To compare antipyret...

Thermal-infrared radiosity and heat-diffusion model for estimating sub-pixel radiant temperatures over the course of a day Iryna Danilina Chair of the Supervisory Committee: Professor Alan Gillespie Department of Earth and Space Sciences In temperature/emissivity estimation from remotely measured radiances the general assumption is that scene elements represented by pixels in fact have a single...

Abstract. In this report the development of a finite volume method for the time-accurate simulation of the temperature distribution in a premature infant inside an incubator or in an open radiant warmer is described. The real geometry of a premature infant is obtained from MRT-images. The infants thermoregulation is modelled by the so-called bio-heat-transfer-equation incorporating source terms...

An analysis is presented of ignition, flame spread, and skin burn associated with the ignition and burning of a multilayered jacket. The important physical processes can all be detailed based on simple thermophysical modeling. The ignition process associated with proximity to a radiant heat source is analyzed to see how a change in external (outer) fabric could have diminished the likelihood of...