نتایج جستجو برای: radiochemotherapy
تعداد نتایج: 1049 فیلتر نتایج به سال:
In extensive disease of small cell lung cancer a doubling of the one-year-survival rate was reported in August 2007 by prophylactic cranial irradiation applied to patients who experienced any response to initial chemotherapy. We discuss the treatment concept of extensive disease in the face of the latest results and older studies with additional thoracic irradiation in this subgroup. A randomiz...
In advanced follicular lymphoma conventional chemotherapy has failed to substantially prolong survival. To improve the outcome, the German Low-Grade Lymphoma Study Group (GLSG) initiated a randomized trial, comparing the effect of a potentially curative myeloablative radiochemotherapy followed by autologous stem cell transplantation (ASCT) to α-interferon maintenance (IFNα) in first remission. ...
OBJECT Communicating hydrocephalus is an uncommon complication in patients treated for glioblastoma multiforme (GBM). Its pathogenesis remains unclear. The authors evaluated the clinical and radiological factors associated with the onset of communicating hydrocephalus and the impact of ventriculoperitoneal (VP) shunt surgery on the outcome of these patients. METHODS One hundred twenty-four pa...
this guideline on an S3 level was performed. This S3 guideline has led to a change of paradigm in the treatment of cervical cancer. With consideration of all relevant currently published studies a principle of unimodal therapy of cervical cancer should be preferred. This means that all patients with histopathologically documented risk factors, e.g., stages G3, L1, or V1 or bulky disease, which ...
BACKGROUND Simultaneous adjuvant platinum-based radiochemotherapy in high-risk cervical cancer (CC) is an established treatment strategy. Sequential paclitaxel (Taxol) and platinum followed by radiotherapy may offer further advantages regarding toxicity. PATIENTS AND METHODS An open-labeled randomized phase III trial was conducted to compare paclitaxel (175 mg/m(2)) plus carboplatin (AUC5) fo...
OBJECTIVE This analysis was performed to assess whether antiepileptic drugs (AEDs) modulate the effectiveness of temozolomide radiochemotherapy in patients with newly diagnosed glioblastoma. METHODS The European Organization for Research and Treatment of Cancer (EORTC) 26981-22981/National Cancer Institute of Canada (NCIC) CE.3 clinical trial database of radiotherapy (RT) with or without temo...
BACKGROUND The aim of the study was to investigate how the expression of tumor markers p21, p27, p53, cyclin D1, EGFR, Ki-67, and CD31 influenced the outcome of advanced inoperable oropharyngeal carcinoma patients, treated with concomitant radiochemotherapy. PATIENTS AND METHODS The pretreatment biopsy specimens of 74 consecutive patients with inoperable stage IV oropharyngeal squamous cell c...
BACKGROUND Squamous cell carcinoma of the head and neck region (HNSCC) is a common malignant disease accompanied by a high risk of local or distant recurrence after curative-intent treatment. Biomarkers that allow for the prediction of disease outcome can guide clinicians with respect to treatment and surveillance strategies. Here, the methylation status of PITX2 and an adjacent lncRNA (PANCR) ...
Mantle-cell lymphoma (MCL) is characterized by poor prognosis with a median survival of only 3 to 4 years. To improve clinical outcome, the European MCL Network initiated a randomized trial comparing consolidation with myeloablative radiochemotherapy followed by autologous stem cell transplantation (ASCT) to alpha-interferon maintenance (IFN alpha) in first remission. Patients 65 years of age o...
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