Division of Molecular Psychiatry, Translational Research Center, University Hospital of Psychiatry, University of Bern, 3000 Bern 60, Switzerland PET Center, Division of Nuclear Medicine, University Hospital, 8091 Zurich, Switzerland Center for Radiopharmaceutical Science of ETH, PSI, and USZ, Department of Chemistry and Applied Biosciences of ETH, 8093 Zurich, Switzerland Novartis Institutes f...

Radiopharmaceuticals are radioactively labeled compounds fulfilling the requirements of pharmaceutical products, used in radio diagnosis or radiotherapy. One essential parameter in the quality control of radiopharmaceuticals is the radionuclidic purity. In this work, we present aspects regarding the radionuclidic purity determination for the radiopharmaceutical products: Sodium Iodide (I) solut...

In single photon emission computed tomography (SPECT) one is interested in reconstructing the activity distribution f of some radiopharmaceutical. The data gathered suffer from attenuation due to the tissue density μ. Each imaged slice incorporates noisy sample values of the nonlinear attenuated Radon transform A(f,μ)(ω, s) = ∫ ∞ −∞ f (sω⊥ + tω) exp (

State Key Laboratory of Molecular Vaccin Molecular Imaging and Translational Med University, Xiamen 361102, People's Repub cn; [email protected] Key Laboratory of Radiopharmaceutical Chemistry, Beijing Normal University, Beijin Department of Control Science and Engine West Dazhi Street, Nan Gang District, Harb † Electronic supplementary informa 10.1039/c6sc04798j Cite this: Chem. Sci., 2017, 8, ...

Background Overexpression of prostatic membrane antigen (PSMA) is associated with the progression and prognosis of prostate cancer. There are numerous studies using this peptide with the 68Ga radionuclide. Previous methods to synthetize 18F-labeled PSMA ligands with complexes [18F]AlF2+ have been achieved. However, these reported syntheses were performed manually, using small volumes. Therefore...

UNLABELLED The objective of this project was to ensure correct radiopharmaceutical administration through the use of a bar code system that links patient and drug profiles with on-site information management systems. This new combined system would minimize the amount of manual human manipulation, which has proven to be a primary source of error. The most common reason for dosing errors is impro...

UNLABELLED The use of (99m)Tc-sulfur colloid lymphoscintigraphy for the determination of lymph flow patterns from a tumor site and localization of the sentinel node has been widely adopted. However, the effects of multiple injections of the radiopharmaceutical can range from mild discomfort to pain. pH-adjusted lidocaine HCl coadministered with (99m)Tc-sulfur colloid presents a risk of introduc...

5-Iodo-3-(2(S)-azetidinylmethoxy)pyridine (5IA), an A-85380 analog iodinated at the 5-position of the pyridine ring, was evaluated as a radiopharmaceutical for investigating brain nicotinic acethylcholine receptors (nAChRs) by single photon emission computed tomography (SPECT). [123/125I]5IA was synthesized by the iododestannylation reaction under no-carrier-added conditions and purified by hig...