نتایج جستجو برای: radioprotection
تعداد نتایج: 740 فیلتر نتایج به سال:
Treatment with essential metalloelement (Cu, Fe, Mn, and Zn) chelates or combinations of them before and/or after radiation injury is a useful approach to overcoming radiation injury. No other agents are known to increase survival when they are used to treat after irradiation, in a radiorecovery treatment paradigm. These chelates may be useful in facilitating de novo syntheses of essential meta...
Despite the large interest in nuclear/optical multimodality imaging, the effect of radiation on the fluorescence of fluorophores remains largely unexplored. Herein, we report on the radiobleaching of cyanine fluorophores and describe conditions to provide robust radioprotection under practical (pre)clinical settings. We determined the radiosensitivity of several cyanine fluorescent compounds, i...
Nitroxide compounds are stable free radicals which were previously investigated as hypoxic cell radiosensitizers. The stable nitroxide 4hydroxy-2,2,6,6-tetramethylpiperidine-JV-oxyl (Tempol) has recently been shown to protect aerated cells in culture against Superoxide gener ated from hypoxanthine/xanthine oxidase, hydrogen peroxide, and radia tion-induced cytotoxicity and to modestly sensitize...
PURPOSE The nitroxide free radical, Tempol, was evaluated for potential differential radiation protection of salivary glands and tumor using fractionated radiation. Mechanistic information was explored by monitoring the presence and bioreduction of Tempol in both tissues noninvasively by magnetic resonance imaging (MRI). EXPERIMENTAL DESIGN Female C3H mice were immobilized using custom-made L...
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