Idiosyncrasy-like liver injury occurs in rats cotreated with nonhepatotoxic doses of ranitidine (RAN) and bacterial lipopolysaccharide (LPS). Hepatocellular oncotic necrosis is accompanied by neutrophil (PMN) accumulation and fibrin deposition in LPS/RAN-treated rats, but the contribution of PMNs to injury has not been shown. We tested the hypothesis that PMNs are critical mediators of LPS/RAN-...

The aim of this preliminary study was to examine the feasibility of a rapid automatic naming (RAN) task for young Spanish–English speaking dual language learners (DLLs) and to examine the relationship between children’s performance on RAN and other standardized language and literacy assessments. A total of 275 Spanish–English speaking children in kindergarten and first grade attempted a RAN tas...

OBJECTIVE To examine childhood perfectionism in anorexia nervosa (AN) restricting (RAN), purging (PAN), and binge eating with or without purging (BAN) subtypes. METHOD The EATATE, a retrospective assessment of childhood perfectionism, and the eating disorder inventory (EDI-2) were administered to 728 AN participants. RESULTS EATATE responses revealed general childhood perfectionism, 22.3% o...

The Ran GTPase plays a critical role in nucleocytoplasmic transport and has been implicated in the maintenance of nuclear structure and cell cycle control. Here, we have investigated its role in nuclear assembly and DNA replication using recombinant wild-type and mutant Ran proteins added to a cell-free system of Xenopus egg extracts. RanQ69L and RanT24N prevent lamina assembly, PCNA accumulati...

Samp1 is a transmembrane protein of the inner nuclear membrane (INM), which interacts with the nuclear lamina and the Linker of Nucleoskeleton and Cytoskeleton (LINC) complex in interphase and during mitosis, it localizes to the mitotic spindle. Samp1 was recently found to coprecipitate a protein complex containing Ran, a GTPase with fundamental regulatory functions both in interphase and in mi...

The analyses of gene duplications by retroposition have revealed an excess of male-biased duplicates generated from X chromosome to autosomes in flies and mammals. Investigating these genes is of primary importance in understanding sexual dimorphism and genome evolution. In a particular instance in Drosophila, X-linked nuclear transport genes (Ntf-2 and ran) have given rise to autosomal retropo...

We study relation algebras with n-dimensional relational bases in the sense of Maddux. Fix n with 3 ≤ n ≤ ω. Write Bn for the class of non-associative algebras with an ndimensional relational basis, and RAn for the variety generated by Bn. We define a notion of relativised representation for algebras in RAn, and use it to give an explicit (hence recursive) equational axiomatisation of RAn, and ...

Ran GTPase plays important roles in nucleocytoplasmic transport in interphase and in both spindle formation and nuclear envelope (NE) assembly during mitosis. The latter functions rely on the presence of high local concentrations of GTP-bound Ran near mitotic chromatin. RanGTP localization has been proposed to result from the association of Ran's GDP/GTP exchange factor, RCC1, with chromatin, b...

Let 2-RAN be the statement that for each real X a real 2-random relative to X exists. We apply program extraction techniques we developed in [10,9] to this principle. Let WKL0 be the finite type extension of WKL0. We obtain that one can extract primitive recursive realizers from proofs in WKL0 +Π 0 1-CP+ 2-RAN, i.e., if WKL0 + Π 0 1-CP+ 2-RAN ` ∀ f ∃xAqf( f ,x) then one can extract from the pro...

1 Recap Last lecture we started to look at how we could realize any two-party functionality for any number of faults in the F CRS-hybrid model. In this lecture we will finish this discussion and extend it to the multi-party case. We will also note that we can get rid of the CRS in the case of an honest majority. All the material in this lecture is taken from [CLOS02]. In more detail, we follow ...