Reflective method invocation is a long known performance bottle neck in Java. Different approaches to optimizing reflective method invocation are adopted by JVMs. In this paper we present an overview of the different approaches and a performance analysis using synthetic and the DaCapo benchmarks. We implement all of the approaches in the Jikes RVM.

The transient receptor potential vanilloid-1 (TRPV1) receptor is involved in peripheral and spinal nociceptive processing and is a therapeutic target for pain. We have shown previously that TRPV1 in the ventrolateral periaqueductal grey (VL-PAG) tonically contributes to brainstem descending antinociception by stimulating glutamate release into the rostral ventromedial medulla and OFF neuron act...

Since compared with the Support Vector Machine (SVM), the Relevance Vector Machine (RVM) not only has the advantage of avoiding the overlearn which is the characteristic of the SVM, but also greatly reduces the amount of computation of the kernel function and avoids the defects of the SVM that the scarcity is not strong, the large amount of calculation as well as the kernel function must satisf...

The rostral ventromedial medulla (RVM) is an important site of opioid actions and forms part of an analgesic pathway that projects to the spinal cord. The neuronal mechanisms by which opioids act within this brain region remain unclear, particularly in relation to the neurotransmitters GABA and serotonin. In the present study, we examined serotonergic and GABAergic immunoreactivity, identified ...

Submitted for the MAR14 Meeting of The American Physical Society Knotting of vortex tangle in three-dimensional random waves ALEXANDER TAYLOR, MARK DENNIS, University of Bristol — Quantised vortices are fundamental to the description of disordered 3D complex scalar fields such as turbulent superfluids or BECs, but also a wide range of other phenomena including optical volume speckle, the quantu...

Using the random matrix theory we demonstrate explicitly the insensitivity of the transverse force on a moving vortex to non-intrinsic and non-magnetic impurities in a superconductor. The Berry phase acquired by a moving vortex suggests that the total transverse force on a moving vortex is proportional to the superfluid density at zero temperature, irrespective whether or not impurities are pre...

Recently, sparse kernel methods such as the Relevance Vector Machine (RVM) have become very popular for solving regression problems. The sparsity and performance of these methods depend on selecting an appropriate kernel function, which is typically achieved using a cross-validation procedure. In this paper we propose a modification to the incremental RVM learning method, that also learns the l...

The midbrain periaqueductal gray (PAG), and its descending projections to the rostral ventromedial medulla (RVM), provide an essential neural circuit for opioid-produced antinociception. Recent anatomical studies have reported that the projections from the PAG to the RVM are sexually dimorphic and that systemic administration of morphine significantly suppresses pain-induced activation of the P...

Brainstem descending control is crucial in maintaining the balance of excitation and inhibition in spinal sensory networks. In the adult, descending inhibition of spinal dorsal horn circuits arising from the brainstem rostroventral medial medulla (RVM) is targeted to neurons with a strong nociceptive C fibre input. Before the fourth postnatal week, the RVM exerts a net facilitation of spinal ne...