BACKGROUND Idiopathic intracranial hypertension (IIH) is a condition with few effective management options. So far, there have been no randomized controlled trials evaluating new treatments in IIH. OBJECTIVES The purpose of this paper is to outline the trial design for the Idiopathic Intracranial Hypertension Drug Trial (IIH:DT), assessing an innovative medical treatment in IIH and the ration...

1. THE NEED FOR A TRIAL 1.1 What is the problem to be addressed? The proposed randomized controlled two-centre pilot trial will assess the feasibility, tolerability and effect size of a program of exercise training to treat the post-thrombotic syndrome (PTS). Results of this pilot trial will be used to plan a larger, adequately powered, multicenter randomized trial of exercise training to treat...

BACKGROUND Trigeminal neuralgia (TN) is a rare severe unilateral facial pain condition. Current guidelines in trigeminal neuralgia management recommend sodium channel blockers--carbamazepine or oxcarbazepine--as the first-line treatment. However, the currently available drugs are often associated with poor tolerability resulting in sub-optimal pain control. CNV1014802 is a novel sodium channel ...

Aurora SK, Dodick DW, Turkel CC, et al.: OnabotulinumtoxinA for treatment of chronic migraine: results from the doubleblind, randomized, placebo-controlled phase of the PREEMPT 1 trial. Cephalalgia 2010, 30: 793–803. Diener HC, Dodick DW, Aurora SK, et al.: OnabotulinumtoxinA for treatment of chronic migraine: results from the double-blind, randomized, placebo-controlled phase of the PREEMPT 2 ...

assisted intravenous catheter placement in a pediatric emergency department. Acad Emerg Med 2011; 18: 966–71 9 Kim M, Park J, Rhee N, et al. Efficacy of VeinViewer in pediatric peripheral intravenous access: a randomized controlled trial. Eur J Pediatr 2012; 171: 1121–5 10 Sanchez-Morago G, Sanchez Coello M, Villafranca Casanoves A, Cantero Almena J, Migallon Buitrago M, Carrero Caballero M. Vi...

BACKGROUND A manualized language therapy developed via a randomized controlled trial had proved efficacious in the short-term in developing expressive language for mainstream primary school children with persistent language impairment. This therapy had been delivered to a predetermined schedule by speech and language therapists or speech and language therapy assistants to children individually ...