The aim of this work is to investigate the impact of placebo response rates on the relative risk of response to drug versus placebo in randomized, double-blind, placebo-controlled clinical trials of pharmacological therapy in Bipolar Depression (BPD). Medline/PubMed publication databases were searched for randomized, double-blind, placebo-controlled trials of oral drugs used as monotherapy for ...

The objective of our study is to quantitatively examine the available evidence regarding the efficacy and side effects of magnesium sulfate for acute tocolysis (from randomized trials) compared with placebo and beta-agonist agents. Randomized trials comparing magnesium sulfate with placebo or beta-agonists for tocolysis were identified with a MEDLINE-based search and was supplemented by a searc...

OBJECTIVE To determine whether placebo-controlled randomized clinical trials of antidepressant medications with pregnant participants are ethically justified. DATA SOURCES We searched PUBMED, PsychINFO, and Cochrane databases for articles related to the ethical justification of randomized placebo-controlled trials involving pregnant women and for all research articles for the treatment of dep...

BACKGROUND AND AIMS Adalimumab has been shown to be efficacious and well-tolerated in Western patients with Crohn's disease. These 2 randomized, double-blind clinical trials evaluated adalimumab efficacy and safety in Japanese patients with moderate to severe Crohn's disease. METHODS 90 patients enrolled in the induction trial and were randomized to receive adalimumab 160/80 mg, adalimumab 80...

DUPISTAD (NCT04033367) evaluated the impact of dupilumab on sleep. Adults with moderate-to-severe AD (EASI ≥12, Pruritus numerical rating scale (NRS) ≥ 3 and sleep NRS ≥5) were randomized 2:1 to 300mg every 2 weeks (q2w) or placebo for 12 (W12); both groups permitted concomitant topical corticosteroids. The primary efficacy endpoint was quality percentage change from baseline W12, assessed by 1...

Immune dysregulation may be involved in the pathophysiology of schizophrenia. Given need for new treatment options schizophrenia, anti-inflammatory medication could a potential this illness. In double-blind, placebo-controlled clinical trial, patients with schizoaffective disorder or psychosis NOS were randomized 1:1 to either prednisolone placebo, addition their regular antipsychotic medicatio...

Abstract Background Magnesium sulphate (MgSO 4 ) has been proven as an analgesic, neuromuscular blocker agent, and treatment of acute asthma. Objective The study aimed to assess the safety efficacy magnesium infusion for patients with atrial fibrillation. Methods A prospective, randomized, double-blind, placebo-controlled was conducted on 55 fibrillation at Emergency Department. group consistin...

OBJECTIVE Randomized, double-blinded, placebo-controlled, clinical trial to determine the effectiveness of palatal implants for treatment of mild/moderate obstructive sleep apnea/hypopnea syndrome (OSAHS). STUDY DESIGN AND SETTING Sixty-two non-obese adults with history of snoring, daytime sleepiness, and mild/moderate OSAHS, were randomized to receive palatal implants (n = 31) or placebo pro...