objective: to evaluate the safety and efficacy of isosorbide mononitrate (imn) as a cervical ripening agent prior to induction of labour in term pregnant women. materials and methods: a randomized placebo-controlled study was conducted on 100 term singleton pregnancies planned for induction of labour. the participants were randomly assigned to two groups. one group received 40 mg imn and the ot...

background: oral aphthous is one of the most common oral mucosal inflammatory disorders which are very painful. there is no definite medical strategy up to now for aphthous treatment. recently, some researchers have focused on immunomodulatory drugs such as tacrolimus and pimecrolimus in preventing aphthus recurrences. the aim of this study is to assess the effect of pimecrolimus cream against ...

conclusions ginger was effective for the relief of mild to moderate nausea and vomiting in pregnant women at less than 16 weeks gestation. results there were no statistical differences in the baseline demographics between the three groups apart from age of marriage and wanted or unwanted pregnancy. an ancova test (covariance test) showed significant differences in mean scores after the interven...

Abstract Background Bacterial infection is an important cause of diarrhea in children, potentially leading to malnutrition, growth and development disorders, even death. Antibiotic abuse resistance are widespread problems worldwide, especially China. We therefore designed a study evaluate the clinical efficacy mechanism traditional Chinese medicine alleviating effects antibiotic childhood bacte...

PURPOSE We evaluated the efficacy and tolerability of mycophenolate mofetil in patients with treatment refractory interstitial cystitis/painful bladder syndrome. MATERIALS AND METHODS A total of 210 patients with interstitial cystitis/painful bladder syndrome were to be randomized into a multicenter, placebo controlled trial using a 2:1 randomization. Participants in whom at least 3 interstit...

BACKGROUND Traumatic brain injury (TBI) is a main cause of severe prolonged disability of young patients. Hospital acquired pneumonia (HAP) add to the morbidity and mortality of traumatic brain-injured patients. In one study, hydrocortisone for treatment of traumatic-induced corticosteroid insufficiency (CI) in multiple injured patients has prevented HAP, particularly in the sub-group of patien...

the effect of sublingual nitroglycerine (tng) on relieving pain in renal and ureteral colic was studied in a randomized, prospective, double blind and placebo controlled clinical trial. one hundred out-patients between 16-60 years of age from either sex who were admitted to the urology emergency center of ayatollah taleghani and ashrafi esfahani hospitals were chosen for this study. they were d...

BACKGROUND Hypertensive intracerebral hemorrhage (HICH) is one of the most devastating forms of stroke. Currently, no specific therapies for HICH except general medical care. However, in China, medicine of promoting blood circulation (PBC) and removing blood stasis (RBS) are widely and efficiently used to treat HICH and become a potentially effective treatment for the secondary effects of HICH ...

Background: Individuals living with Alzheimer’s disease (AD) demonstrate extensive deficits in social cognition. To date, no studies have investigated the feasibility of an intranasal oxytocin (INOT) treatment to improve cognition individuals AD. Objective: We conducted a pilot trial determine recruitment feasibility, enrolment acceptability, and adherence INOT inform on subsequent design futur...

BACKGROUND With increasing human longevity there is increasing prevalence of osteoporosis and of osteoporotic vertebral fractures. Most vertebral fractures do not require medical therapy for pain, but a minority are associated with severe pain and disability. Vertebroplasty has been used increasingly for painful acute osteoporotic fractures. The best available evidence for vertebroplasty is pro...