DOI: 10.5581/1516-8484.20130001 On January 14th 2013, the results of the International Consortium on Acute Promyelocytic Leukemia (IC-APL)(1) were published online in the journal Blood. Eight Brazilian institutions participated in the IC-APL: the Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (USP) as coordinator, the Hematology Divisions of the Universidades Federal do Rio ...

BACKGROUND DNA methyltransferase 3A (DNMT3A) mutations have been found in approximately 20% of adult acute myeloid leukemia (AML) patients and in 0% to 1.4% of children with AML, and the hotspots of mutations are mainly located in the catalytic methyltransferase domain, hereinto, mutation R882 accounts for 60%. Although the negative effect of DNMT3A on treatment outcome is well known, the progn...

Retinoic acid receptors (RARs) are hormone-regulated transcription factors that control key aspects of normal differentiation. Aberrant RAR activity may be a causal factor in neoplasia. Human acute promyelocytic leukemia, for example, is tightly linked to chromosomal translocations that fuse novel amino acid sequences (denoted PML, PLZF, and NPM) to the DNA-binding and hormone-binding domains o...

RATIONALE Acute promyelocytic leukemia (APL) is a curable subtype of acute myeloid leukemia. APL is currently treated with combination of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) resulting in the induction of apoptosis and differentiation of the leukemic cells. Differentiation syndrome (so-called ATRA syndrome) is the main life-threatening complication of induction therapy with...

Acute promyelocytic leukemia (APL) is a hematopoietic malignant disease characterized by the chromosomal translocation t(15;17), resulting in the formation of the PML-RARA gene. Here, 47 t(15;17) APL samples were analyzed with high-density single-nucleotide polymorphism microarray (50-K and 250-K SNP-chips) using the new algorithm AsCNAR (allele-specific copy-number analysis using anonymous ref...

which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. A 26-year-old man visited our hospital for the evaluation of leukopenia, an incidental finding during a routine health examination. His complete blood count values were as follows: leukocytes, 1.09×10 dry tap with unremarkable finding. On touch imprints, how...

Retinoic acid receptor (RAR) a has been shown to play a role in retinoid-induced growth Inhibition of human breast cancer cell lines that express the estrogen receptor (ER). The dogma in the field has been that ER-positive breast cancer cell lines respond to retinoid treatment because they express RARa, whereas ER-negative breast cancer cell lines are refractory to retinold treatment and have b...

n engl j med 369;2 nejm.org july 11, 2013 186 Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia (AML) that is characterized by abnormal promyelocytes, a lifethreatening bleeding syndrome, and t(15;17) chromosomal translocation. APL used to be the worst form of leukemia.1,2 The introduction of anthracycline-based chemotherapy in the 1970s yielded a complete remis...

A prenatal origin of translocations associated with pediatric leukemia has been demonstrated for MLL-AF41 in infant leukemia, TEL-AML12,3 in common acute lymphocytic leukemia (cALL), and AML1-ETO4 in acute myeloid leukemia (AML). We investigated whether AML-associated translocations PML-RARA and CBFB-MYHII could arise before birth. PML-RARA arises from the t(15;17) translocation,5 characteristi...