Intracellular calcium concentration has been proposed as the key associative signal for the Hebbian synaptic plasticity. The Unified Calcium Model has been able to account for various plasticityinduction protocols, such as rate-based and spike time-dependent plasticity. Here, we investigate the properties of this model in a multi-synapse neuron receiving inputs with different spatiotemporal spi...

We examine the conditions under which spike-timing-dependent plasticity (STDP) normalizes post-synaptic 0ring rates. Our simulations show that the rate normalization property of STDP is fragile and small changes in the LTD=LTP ratio or pre-synaptic input rates can lead to high 0ring rates. We propose an adaptive scheme to dynamically control the LTP=LTD ratio. The biophysics of synapses lead us...

We couple a previously studied, biologically inspired neurotrophic model of activity-dependent competitive synaptic plasticity and neuronal development to a neuromorphic retina chip. Using this system, we examine the development and refinement of a topographic mapping between an array of afferent neurons (the retinal ganglion cells) and an array of target neurons. We find that the plasticity mo...