The short QT syndrome (SQTS) is a genetically heterogeneous condition characterized by abbreviated QT intervals and an increased susceptibility to arrhythmia and sudden death. This simulation study identifies arrhythmogenic mechanisms in the rapid-delayed rectifier K(+) current (I(Kr))-linked SQT1 variant of the SQTS. Markov chain (MC) models were found to be superior to Hodgkin-Huxley (HH) mod...

Auxetic materials or with a negative Poisson's ratio have great potential to be used in many industries because of their specific mechanical properties such as high stiffness and strength significant weight saving. In this article, the effect various parameters fabrication process on microstructure polyurethane auxetic foam was investigated. Moreover, compression behavior different situations, ...

An extensible semiflexible filament moving on a motility assay of motor proteins undergoes first order re-entrant phase transition from open chain to spiral as function the extension rate and turnover proteins.

We consider the Poisson equation −∆u = f with homogeneous Dirichlet boundary condition on a two-dimensional polygonal domain Ω with re-entrant angles. A multigrid method for the computation of singular solutions and stress intensity factors using piecewise linear functions is analyzed. When f ∈ L2(Ω), the rate of convergence to the singular solution in the energy norm is shown to be O(h), and t...

We investigated the effect of various spectral manipulations on the identification of sentential prosody. Two main categories of prosody--affective (happy, angry, sad) and linguistic (statement, question, continuation)--were studied. Thirty-six subjects were presented with stimuli that were recorded by a female native speaker of American English. The stimuli were digitally manipulated to create...

Negative Poisson's ratio foam was used in the development of seat cushions which exert reduced peak pressure upon the skin of seated persons. Foam processing techniques were scaled up. A longer processing time was required for cushion size samples in comparison with small samples. Pressure distributions on a seated subject were measured using a pressure-sensitive array. Seated pressure distribu...

Idiopathic monomorphic ventricular tachycardia and premature ventricular complexes (PVCs) commonly arise from the right and left ventricular outflow tracts (VOT). Their mechanism is most commonly triggered activity from delayed after-depolarizations and successful ablation is performed at the site of earliest endocardial activation. Re-entrant mechanisms have been rarely described. We report a ...

The presence of hot lots or high-priority jobs in semiconductor manufacturing systems is known to significantly affect the cycle time and throughput of the regular lots since the hot lots get priority at all stages of processing. In this paper, we present an efficient analytical model based on re-entrant lines and use an efficient, approximate analysis methodology for this model in order to pre...

We present spatio-temporal characteristics of spreading depolarizations (SD) in two experimental systems: retracting SD wave segments observed with intrinsic optical signals in chicken retina, and spontaneously occurring re-entrant SD waves that repeatedly spread across gyrencephalic feline cortex observed by laser speckle flowmetry. A mathematical framework of reaction-diffusion systems with a...

Environmental stress testing (EST) is a reliability test for the semiconductor products that is concerned with how products perform its intended functions under some environmental conditions. Planning, implementation and delivery schedules are affected by the outcome of these tests and it is crucial to determine the throughput of the EST process. In this paper we present an efficient modified a...