Colorectal lesions termed squamous morules or microcarcinoids display predominantly squamous and variable endocrine differentiation and are often found in colorectal adenomas with high grade dysplasia thus mimicking invasion. Herein, we describe histopathologic, immunohistochemical classification and clinical correlation of analogous lesions in the esophagus and stomach. We identified five case...

SUMMARY Histological and histochemical studies of livers from rats sacrificed at intervals after they were fed 3'-methyl-4-dime-thylaminoazobenzene for 46 days suggest that there are two different pathways of progression from preneoplastic lesions to hepatic carcinomas. In one sequence, hepatocytes that were deficient in glucose 6-phosphatase and formed prominent hyperplastic nodules appeared t...

BACKGROUND Benign hyperplastic thymus is a rare but important differential diagnosis of anterior mediastinal lesions. Histological and radiological criteria are used to distinguish this benign condition from other malignant diseases but have their limitations, and biopsy of mediastinal masses can be risky. We report for the first time the diagnostic value of fluorodeoxyglucose 18F positron emis...

Alveolar type II cells arising in canine bronchial autografts following exposure to 3-methylcholanthrene (MCA) give rise to carcinomas of varying glandular and squamous growth patterns. To study the role of the tumor suppressor gene p53 in this process, sections from progressive lesions were immunostained for p53 protein; microdissected regions were screened for p53 mutations. Adjacent sections...

OBJECTIVE To document the histopathological pattern and distribution of reactive localised inflammatory hyperplastic lesions of the oral mucosa diagnosed at the University of Nairobi Dental Hospital over a 14 year period. DESIGN A retrospective, cross-sectional descriptive study. SETTING Division of Oral Pathology and Oral Medicine, histopathology laboratory, School of Dental Sciences, Univ...

Introduction: Few studies on benign soft tissue tumors of oral cavity have been conducted in an Iranian population. The purpose of this study was to evaluate the prevalence of the benign soft tissue tumors of the oral cavity in three central pathology centers of Rasht, Iran. Materials and Methods: In this retrospective study, all benign soft tissue tumors of the oral cavity, were retrieved fro...

Early detection of oral squamous cell carcinoma (OSCC) and potentially malignant disorders (OPMD) is important for dental professionals to improve patient survival rates. More than half patients with cancer had advanced disease at the time diagnosis, indicating a lack early risk assessment biomarkers. The development new protein biomarkers will help in diagnosis treatment.The argyrophilic nucle...

PURPOSE It has been reported that approximately a million women are diagnosed with benign breast lesions that include ductal hyperplasias per year in the United States. Recent studies that followed women with benign lesions have established that about 8% to 9% of them will subsequently develop invasive breast cancer (IBC). However, currently, there are no means of identifying a subclass of "tru...

In spite of the evidence that the malignant transformation of gastric hyperplastic polyps (HPs) is a rare event, it must always be taken into account during diagnosis. The aim of the current study was to clarify the mechanism of the malignant transformation of gastric hyperplasia polyps, with focus on phenotypic expression, cell proliferation and p53 overexpression. Immunohistochemistry for muc...

BACKGROUND Biopsy and polypectomy frequently are performed for lesions that carry a low risk of malignant transformation in the colon. Elastic scattering spectroscopy (ESS) is a novel optical biopsy technique that can distinguish, almost instantaneously, between normal and abnormal tissue in vivo, without the need to remove tissue. We assessed the diagnostic potential of ESS in the colon to dif...