background: macrophage immune responses are affected by the secretory proteins of mycobacterium tuberculosis (mtb). this study aimed to examine the immune responses of macrophages to mtb secretory antigens, namely esat-6, cfp-10, and esat-6/cfp-10. methods: thp-1 cells (a human monocytic cell line) were cultured and differentiated to macrophages by phorbol 12-myristate 13-acetate. the cytotoxic...

Background: Preterm premature rupture of membranes (PPROM) and preterm birth results in one third perinatal mortality maternal morbidity such as chorioamnionitis abruption placenta caesarean section, occurs 3% pregnancies. PPROM is associated with intrauterine infection. Early detection infection may help prevent neonatal sepsis. Objective present study was to analyse the outcome patients betwe...

recent studies show that, inflammation plays an important role in the initiation and progression of atherosclerosis and in the pathogenesis of acute cardiovascular events. there is a possible association between ventricular dysfunction following acute myocardial infarction and high sensitivity c-reactive protein (hs-crp) and uric acid. in this study we assessed the relationship between hs-crp a...

background: polycystic ovary syndrome (pcos), a common endocrine disorder, is associated with infertility, menstrual dysfunction, hirsutism and frequent miscarriages. insulin resistance, as a major cause of pcos, represents a disorder with increase in inflammatory markers and risk of type 2 diabetes. we aimed to investigate whether inflammatory markers, including c-reactive protein and c3 (comp...

conclusions while the crp value was in patients with acute brucellosis in the current study, the mpv, rdw and leukocyte counts were within the normal range. crp value remains the most valuable inflammatory marker in cases of acute brucellosis. results the follow-up within the year after treatment was examined. the values of age, gender, leukocyte count, c-reactive protein, rdw and mpv were reco...

background: several factors are associated with the development or exacerbation of pain in knee osteoarthritis (koa). in this study, we reviewed this context based on relevant studies. methods: recent published studies which have addressed the relationship between pain and koa were summarized. results: correlates of the clinical, demographic features, laboratory tests and abnormalities on radio...

To determine the diagnostic utility of serum calprotectin, a mediator of innate immune response against infections, we performed a multicenter study involving newborns with a birth weight < 1500 g and a postnatal age >72 hours of life. The diagnostic accuracy of serum calprotectin was compared with that of the most commonly used markers of neonatal sepsis (white blood cell count, immature-to-to...

background: psoriasis is a chronic and inflammatory dermatologic disease. inflammatory biomarkers such as c-reactive protein (crp) and erythrocyte sedimentation rate (esr) are known as immediate and delayed inflammatory biomarkers, respectively. due to the fact that anti-inflammatory drugs such as infliximab are widely used in psoriasis treatment, the aim of this study was to evaluate esr, crp ...

background: endometriosis is defined as the existence of endometrial-like tissue outside the uterus. diagnosis of endometriosis is a challenging theme. despite the broad search for innovative laboratory tests and advances in imaging technologies, there are still no easy, non-invasive diagnostic tests available. due to inflammatory process of endometriosis, still c-reactive protein (crp) level m...