Recombination-mediated pathways for telomere lengthening may be utilized in the absence of telomerase activity. The RecQ-like helicases, BLM and Sgs1, are implicated in recombination-mediated telomere lengthening in human cells and budding yeast, respectively. Here, we show that BLM expression rescues disrupted telomere lengthening in telomerase-negative sgs1 yeast. BLM helicase activity is req...

Bloom's syndrome (BS) is a rare autosomal recessive disorder characterized by genomic instability and cancer predisposition. The underlying genetic defect is mutation of the BLM gene, producing deficiency in the RecQ helicase BLM (Bloom's syndrome protein). The present article begins by introducing BLM and its binding partners before reviewing its known biochemical activities and its potential ...

Superfamily II (SF-II) RecA (tandem pair) Monomer (dimer/ multimer) 3′-5′ (SF-IIA), 5′-3′ (SF-IIB), some dsDNA translocases RNA melting, RNA-binding protein displacement; DNA or RNA unwinding;chromatin remodeling; DNA/ RNA translocation; melting and migration of Holliday junctions or branched structures DExD/H-box proteins (eukaryotic eIF4A, Prp2, Ski2, Vasa, Dpbs, NS3 of hepatitis C); Snf2/SWI...