Recurrent pregnancy loss (RPL), recurrent miscarriage or habitual abortion is a multifactorial problem with exasperating and challenging aspects in reproductive medicine. It is defined as two or more consecutive loss of clinical pregnancies. However, the incidence of RPL is less than 5% in pregnant women but its etiology is diverse and varied and also for more than 50% of cases is not clearly d...

ObjectiveTo develop diagnostic criteria for chronic endometritis and compare the prevalence of between women with recurrent pregnancy loss (RPL) controls.DesignCohort study.SettingSingle academic fertility center.PatientsWomen unexplained RPL (two or more losses) prospectively recruited controls without a history infertility.InterventionsEndometrial samples were stained hematoxylin eosin CD138....

INTRODUCTION In Mexico, the information available about the prevalence of uterine anatomical anomalies as the direct and indirect cause of recurrent pregnancy loss (RPL) is limited. OBJECTIVE To know the prevalence and types of uterine anatomical anomalies in Mexican women with RPL. METHODS In a cross-sectional study, we included women attending a clinic for RPL from 2008 to 2013, with a hi...

BACKGROUND It is estimated that about 50% of causes of recurrent pregnancy loss (RPL) cases remain unknown. Sperm factors are suggested to have probable role in cases with RPL. OBJECTIVE The goal was to determine the possible relationship between semen bacterial contaminations with unexplained RPL. Also, the correlation between number of bacterial colony and sperm chromatin condensation was e...

The distribution of factor V Leiden G1691A, II G20210A, MTHFR C677T, and H1299R polymorphisms known to predispose thrombophilia in 215 cases 40 controls admitted with indication recurrent pregnancy loss (RPL) was investigated. Genotyping performed by melting curve analysis using simultaneous PCR (RT-PCR). There no difference between genotype allele frequencies the case control groups terms exam...

BACKGROUND Recurrent pregnancy loss is (RPL) a heterogeneous condition. While the role of acquired thrombophilia has been accepted as an etiology for RPL, the contribution of specific inherited thrombophilic gene polymorphisms to the disorder has been remained controversial. METHODS One hundred women with a history of two or more consecutive abortions and 100 women with at least two live birt...

STUDY QUESTION Are mutations in NLRP2/7 (NACHT, LRR and PYD domains-containing protein 2/7) or KHDC3L (KH Domain Containing 3 Like) associated with recurrent pregnancy loss (RPL) or infertility? SUMMARY ANSWER We found no evidence for mutations in NLRP2/7 or KHDC3L in unexplained RPL or infertility. WHAT IS KNOWN ALREADY Mutations in NLRP7 and KHDC3L are known to cause biparental hydatidifo...

Immigrant and resident leukocytes are the main immune components of endometrial and decidual tissue. Altered immune responses have been suspected to be involved in idiopathic recurrent pregnancy loss (RPL) pathogenesis. We aimed to investigate the plasma cytokine levels and endometrial leukocyte subpopulations of RPL cases. This study was conducted with 60 idiopathic RPL (28 primary and 32 seco...

BACKGROUND Women with recurrent pregnancy loss (RPL) and T-helper (Th)1-type immunity to trophoblast antigens have an increased frequency of the IL1B-511*1 promoter variant. Since CD46 gene products also regulate maternal immune responses including Th1 immunity, we investigated whether CD46 gene polymorphisms are also associated with RPL in women with and without Th1 immunity to trophoblast, an...

Objectives: To retrospectively and prospectively investigate the pregnancy outcomes after hysteroscopy (H/S) for septum resection in patients detected to have a uterine presenting with history of recurrent loss (RPL), diagnosis secondary infertility or primary infertility.
 Methods: This study included 62 RPL who underwent hysteroscopic resection. Patients had anomalies other than septum, ...