Peroxisome division involves the conserved PEX11 peroxisomal membrane proteins and in yeast has been shown to require Vps1p, a dynamin-like protein. We show here that DLP1, the human homolog of the yeast DNM1 and VPS1 genes, plays an important role in peroxisome division in human cells. Disruption of DLP1 function by either RNA interference or overexpressing dominant negative DLP1 mutants cause...

The mammary secretory cell population increases in an exponential fashion during pregnancy in all species studied, as a consequence of very high rates of cell division. After parturition the mitotic index drops dramatically, but a limited amount of proliferation does continue, at least until the time of maximum milk yield. This is particularly true of rodents but also occurs in dairy species. D...