The nuclear lamina is a karyoskeletal structure at the nucleoplasmic surface of the inner nuclear membrane. Its assembly state is regulated by phosphorylation of the intermediate filament type lamin proteins. Strong evidence has been obtained for a causal link between phosphorylation of lamins by the p34cdc2 protein kinase and disassembly of the nuclear lamina during mitosis. In contrast, no in...

A major challenge in organophosphate (OP) research has been the identification and utilization of reliable biomarkers for the rapid, sensitive, and efficient detection of OP exposure. Although Tyr 411 OP adducts to human serum albumin (HSA) have been suggested to be one of the most robust biomarkers in the detection of OP exposure, the analysis of HSA-OP adduct detection has been limited to tec...

This work sought to analyze in high resolution the downscaling of global model Climate Forecast System Version 2 (CFSv2) by using regional climate RegCM-4.9. The precipitation fields were generated two different domains and spatial with 10 km 3 km, for August October 2020. equatorial region Northeast Brazil can be characterized complex dynamics that encompass atmospheric movements such as exist...