objective: signaling pathways such as extracellular regulated kinase/mitogen activated protein kinase (erk/mapk) have increased activity in leukemia. ribosomal 6 kinase (rsk4) is a factor downstream of the mapk/erk pathway and an important tumor suppressor which inhibits erk trafficking. decrease in rsk4 expression has been reported in some malignancies, which leads to an increase in growth and...

the non-commuting graph $nabla(g)$ of a non-abelian group $g$ is defined as follows: its vertex set is $g-z(g)$ and two distinct vertices $x$ and $y$ are joined by an edge if and only if the commutator of $x$ and $y$ is not the identity. in this paper we 'll prove that if $g$ is a finite group with $nabla(g)congnabla(bs_{n})$, then $g cong bs_{n}$, where $bs_{n}$ is the symmetric group of degre...

Objective(s): Non-alcoholic steatohepatitis (NASH) is defined by steatosis and inflammation in the hepatocytes, which can progress to cirrhosis and possibly hepatocellular carcinoma. However, current treatments are not entirely effective. Allantoin is one of the principal compounds in many plants and an imidazoline I receptor agonist as well. Allantoin has positive eff...

comparison of the effect of concept mapping and nursing process on self-regulated learning, self-efficacy and cognitive strategies in nursing students     rezaei k [1] *, kouhestani h [2] , nejat n [3] , ebrahimi fakhar h [4]     received: 12 oct , 2011 accepted: 20 jan , 2012     abstract   background & aims : the success of nursing students depends on the understanding of complex concepts and...

<p style='text-indent:20px;'>The aim of this paper is to study a wide class non-convex sweeping processes with moving constraint whose translation and deformation are represented by regulated functions, i. e., functions not necessarily bounded variation admitting one-sided limits at every point. Assuming that the time-dependent uniformly prox-regular has non-empty interior, we prove exist...

Introduction: GTPase regulator associated with focal adhesion kinase (GRAF) is a recently identified GTPase activating protein that has the tumor suppressor properties. However, the expression level of GRAF in leukemia had received less attention. The main purpose of this research was the evaluating of the expression level of GRAF in patients with acute myeloid leukemia (AML). Materials and met...

Background: MLKL, one of the main downstream components of the necroptosis or programmed necrosis has recently been demonstrated in advanced atherosclerotic lesions. However, its precise role in the atherosclerosis pathogenesis still requires more elucidation. Our study was set to delineate both the changes in peripheral MLKL gene expression and its influence on disease severity in atherosclero...