Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in developed countries. The role of complement in the development of AMD is now well-established. While some studies show evidence of complement dysregulation within the eye, others have demonstrated elevated systemic complement activation in association with AMD. It is unclear which one is the primary driver ...

Age-related macular degeneration (AMD) is the most common cause of irreversible visual impairment in older populations in industrialized nations. AMD is a late-onset deterioration of photoreceptors and retinal pigment epithelium in the central retina caused by various environmental and genetic factors. Great strides in our understanding of AMD pathogenesis have been made in the past several dec...

To determine the perceived relevance and value of an individualized measure of the impact of macular degeneration on quality of life (QoL) for elderly people with Age-Related Macular Degeneration (AMD) in the USA, through the assessment of the suitability of the measure's domains and by gaining a deeper insight into the impact of AMD on patients' QoL vis-á-vis these domains, community-dwelling ...

OBJECTIVE To determine the long-term effect of photodynamic therapy (PDT) with verteporfin for age-related macular degeneration (AMD) and non-AMD in Thailand and to compare with the Treatment of Age-Related Macular Degeneration with Photodynamic Therapy (TAP) and Verteporfin in Photodynamic Therapy (VIP) study. MATERIAL AND METHOD The data of patients who received PDT between July 2003 and De...

Objective: The objective of this study was to evaluate the association serum leptin levels with presence and severity age-related macular degeneration (AMD). Methods: A hospital-based case–control conducted on 84 patients (42 cases 42 controls) either sex complaining diminution vision aged 40 years above between August 2019 2021. Results: Mean level in 1.55±0.99 ng/mL control 2.11±0.88 (p<0....

Purpose: To investigate the cytokine concentrations of aqueous humor in patients with exudative age-related macular degeneration (AMD) and diabetic edema (DME).Methods: Fifty-seven subjects were included AMD, DME control groups, each group has 19 patients. Aqueous levels cytokines epidermal growth factor (EGF), vascular endothelial factor-C (VEGF-C), monocyte chemoattractant protein-1 (MCP-1), ...

Age-related macular degeneration (AMD) is one of the leading causes blindness in elderly, affecting macula retina and resulting vision loss. There are two types AMD, wet dry, both which cause visual impairment. Wet AMD called neovascular (nAMD) characterized by formation choroidal vessels (CNVs) macula. nAMD can be treated with intravitreal injections vascular endothelial growth factor (VEGF) i...

Purpose: To evaluate anxiety, depression status, and vision-related quality of life (QoL) in patients with age-related macular degeneration (AMD) during the early phase COVID-19 pandemic. Results: There was no statistically significant difference HADS-A HADS-D between AMD group controls (p<0.05) When were assigned to two distinct groups according binocular visual acuity, proportion above HAD...

There is growing evidence that the pathogenesis of retinal diseases such as diabetic retinopathy (DR) and age-related macular degeneration (AMD) have a significant chronic inflammatory component. A vital part cascade through activation pattern recognition receptors (PRR) toll-like (TLR). Here, we reviewed past current literature to ascertain cumulative knowledge regarding effect TLRs on develop...

800x600 years ago, it was thought that a genetic component was the fundamental cause of a number retinopathy diseases including age related macular degeneration (amd). since then, information has emerged about novel genes that contribute to various forms of amd and other retinopathies that have been eluding researchers for years. in the genetic sense, only the apoe 2 and 4 genes have been found...