In the past decade, many strategies have been developed to enhance oral drug delivery. Different techniques were investigated, amongst those the use of permeation enhancers such surfactants and biodegradable polymers were studied more extensively. Chitosan derivatives have been studied as permeation enhancer in free soluble form and as nanoparticulate systems. The aim of the current work wa...

Novel allosteric modulators of the dopamine transporter (DAT) have been identified. We have shown previously that SRI-9804 [N-(diphenylmethyl)-2-phenyl-4-quinazolinamine], SRI-20040 [N-(2,2-diphenylethyl)-2-phenyl-4-quinazolinamine], and SRI-20041 [N-(3,3-diphenylpropyl)-2-phenyl-4-quinazolinamine] partially inhibit [I]RTI-55 ([I]3b-(49-iodophenyl)tropan-2b-carboxylic acid methyl ester) binding...

The easy and scalable synthesis, biocompatibility, one-dimensionality, high aspect ratio, viability for surface modifications, the ability cargo-loading release make organic nanotubes ideal candidates smart coatings with slow controlled corrosion inhibitors anti-biofouling agents. wide-ranging applicability of as nanocarriers anti-corrosion is foreseen.

INTRODUCTION Latent tuberculosis infection is detected by the tuberculin skin test before treating with anti-Tumour-Necrosis factor alpha (anti TNFα) reagents. More accurate are Interferon gamma release assays (IFNγ release assays) to identify patients with latent tuberculosis. Because of a positive control in this assay, it is possible to identify those patients in which a result of tuberculos...