(b) For patients with pronounced clinical features of acute pyelonephritis where rapid control to limit renal damage is desirable. (c) For patients known to have extensive renal damage where there is a danger of infection precipitating renal failure as well as extending the renal lesion. (d) Post-operative patients where oral therapy is impracticable or where absorption is in doubt. Finally, we...

Experimental studies incriminate glomerular hypertension in mediating progressive renal damage after any of a variety of initiating injuries. Prevention of glomerular hypertension by dietary protein restriction or antihypertensive therapy lessens progressive glomerular damage in several experimental models of chronic renal disease. Glomerular hypertension and hyperfiltration also occur in human...

Glomerulonephritis is an important cause of renal failure thought to be caused by autoimmune damage to the kidney. While each type of glomerulonephritis begins with a unique initiating stimulus, subsequent common inflammatory and fibrotic events lead to a final pathway of progressive renal damage. In this article the different forms of inflammatory glomerulonephritis and their diagnosis are dis...

(b) For patients with pronounced clinical features of acute pyelonephritis where rapid control to limit renal damage is desirable. (c) For patients known to have extensive renal damage where there is a danger of infection precipitating renal failure as well as extending the renal lesion. (d) Post-operative patients where oral therapy is impracticable or where absorption is in doubt. Finally, we...

Docherty, Neil G., Orfhlaith E. O’Sullivan, Declan A. Healy, John M. Fitzpatrick, and R. William G. Watson. Evidence that inhibition of tubular cell apoptosis protects against renal damage and development of fibrosis following ureteric obstruction. Am J Physiol Renal Physiol 290: F4–F13, 2006; doi:10.1152/ ajprenal.00045.2005.—Ureteric obstruction is frequently encountered in primary care urolo...