We describe our observations concerning differences in two groups of young hypertensive patients according to their renin activities after ACE inhibition. Seventeen of these patients (age 26 +/- 7 years), so far untreated, were investigated prospectively for hormone levels (renin, aldosterone, vasopressin), microalbuminuria, renal haemodynamics (inulin and PAH clearance) and signs of organ dama...

Normal renin synthesis and secretion is important for the maintenance of juxtaglomerular apparatus architecture. Mice lacking a functional Ren1d gene are devoid of renal juxtaglomerular cell granules and exhibit an altered macula densa morphology. Due to the species-specificity of renin activity, transgenic mice are ideal models for experimentally investigating and manipulating expression patte...

Correlates of peripheral plasma renin activity were studied in 31 normotensive subjects and 93 untreated hypertensive patients. The latter were grouped according to apparent type of hypertension: essential (58), renovascular (21), renal parenchymal disease (11), and primary aldosteronism (3). Plasma renin activity was inversely correlated with total blood and plasma volumes in normal men, men w...

Background: Postural orthostatic tachycardia syndrome (POTS) is a heterogeneous condition predominantly affecting autonomic control of the cardiovascular system. Its extensive symptom diversity implies multi-organ involvement that interacts in ways still requiring full exploration. Current understanding POTS pathophysiology suggests alterations renin–angiotensin–aldosterone system as possible c...

Correlates of peripheral plasma renin activity were studied in 31 normotensive subjects and 93 untreated hypertensive patients. The latter were grouped according to apparent type of hypertension: essential (58), renovascular (21), renal parenchymal disease (11), and primary aldosteronism (3). Plasma renin activity was inversely correlated with total blood and plasma volumes in normal men, men w...

The interrelationships of arterial pressure, plasma volume (PV), and plasma renin activity were studied in 152 consecutive male patients with uncomplicated essential hypertension. Of these, 22 (17 white and 5 black) subjects had normal plasma volumes and because of the small number were not included in the analysis of results. The remaining 130 (35 black and 95 white) patients were classified a...

Aliskiren Therapy Will Have Minimal Effect on Intracellular Renin of Renin-Producing Cells To the Editor: Krop et al1 reported an interesting study of the effects of aliskiren on intracellular renin and concluded that aliskiren accumulates in renin granules of renin-producing cells. There is, however, concern about the relevance of these data to subjects receiving aliskiren therapy. Krop et al1...

Studies in vitro and in vivo have implicated nitric oxide in the control of renin secretion. In the present study, the effect of inhibition of nitric oxide synthesis with A^°-nitroL-arginine methyl ester hydrochloride (L-NAME) on the renin secretory response to /3-adrenergic stimulation was investigated in conscious, chronically prepared rabbits. Intravenous infusion of isoproterenol at 0.02 fi...

1. Serial changes in plasma renin activity and plasma angiotensin levels were followed in rats during acute renal failure induced by mercuric chloride or glycerol. 2. During mercuric chloride-induced acute renal failure there were transitory large increases in plasma renin and angiotensin. In contrast, rats with acute renal failure produced by glycerol had a reduction in plasma renin and angiot...