Floating structures are designed in such way that the appearance of fatigue failures cannot be avoided, implying the need for inspections during their life. Their maintenance has to be planned from an economic point of view so as to minimize maintenance costs but satisfying a minimum reliability level. A method is proposed to quantify the repair costs resulting of different reliability-based ma...

The emphasis of the present study is on the evaluation of reliability measures of a computer system with independent hardware (h/w) and software (s/w) failures. A single repair facility is provided immediately for conducting repair activities of h/w and s/w. Preventive maintenance of the system is done after a maximum operation time. Replacement of the h/w by new one is made in case server fail...

Abstract Fanconi Anemia (FA) is a rare inherited hematological disease, caused by mutations in genes involved the DNA interstrand crosslink (ICL) repair. Up to date, 22 have been identified that encode series of functionally associated proteins recognize ICL lesion and mediate activation downstream repair pathway including nucleotide excision repair, translesion synthesis, homologous recombinat...

Heterochromatin contains a significant part of nuclear DNA. Little is known about the mechanisms that govern heterochromatic DNA stability. We show here that in the yeast Saccharomyces cerevisiae (i) DNA mismatch repair (MMR) is required for the maintenance of heterochromatic DNA stability, (ii) MutLα (Mlh1-Pms1 heterodimer), MutSα (Msh2-Msh6 heterodimer), MutSβ (Msh2-Msh3 heterodimer), and Exo...

Earth pressure balance tunnel boring machines (EPB-TBMs) are favorably applied in urban tunneling projects. Despite their numerous advantages, considerable delays and high maintenance cost are the main disadvantages these machines suffer from. Reliability, availability, and maintainability (RAM) analysis is a practical technique that uses failure and repair dataset obtained over a reasonable ti...

In this paper we investigate the mathematical modelling of imperfect maintenance of a system under competing risk The model we propose is strongly motivated by Brown Proschan s imperfect repair model but extended to model preventive maintenance as one of several competing risks Parameter estimation in the model is based on Markov Chain Monte Carlo simulation The method is tested using a real li...

In this paper we consider a k-out-of-N system with identical, repairable components under a condition-based maintenance policy. Maintenance consists of replacing all failed and/or aged components. Next, the replaced components have to be repaired. The system availability can be controlled by the maintenance policy, the spare part inventory level, the repair capacity and repair job priority sett...

Cold agglutinins are of unique relevance in cardiac surgerybecause of the use of hypothermic cardiopulmonary bypass (CPB). Cold autoimmune diseases are defined by the presence of abnormal circulating proteins (usually IgM or IgA antibodies) that agglutinate in response to a decrease in body temperature. These disorders include cryoglobulinemia and cold hemagglutinin disease.Immunoglobulin M aut...

This paper considers replacement polices for an extended cumulative damage model with minimal maintenance at each shock and minimal repair at failure: A system is replaced at time T or at shock number N , and undergoes maintenance or repair between replacements. The expected cost rate is obtained and each optimal T ∗ and N∗ to minimize the cost rate is discussed. It is shown that this model wou...