Video and computer games are among the most complex forms of interactive media. Games simulate many elements of traditional media, such as plot, characters, sound and music, lighting and mise-én-scene. However, games are digital artifacts played through graphic interfaces and controllers. As interactive experiences, games are a host of player challenges ranging from more deliberate decision-mak...

BACKGROUND In drug development, a 4-phase hierarchical model for the clinical evaluation of new pharmaceuticals is well known. Several comparable phased evaluation schemes have been proposed for medical tests. PURPOSE To perform a systematic search of the literature, a synthesis, and a critical review of phased evaluation schemes for medical tests. DATA SOURCES Literature databases of Medli...

The area if iterative learning control (ILC) has emerged from robotics to form a new and exciting challenge for control theorists and practitioners. There is great potential for applications to systems with a naturally repetitive action where the transfer of data from repetition (trial or iteration) can lead to substantial improvements in tracking performance. Although many of the challenges me...

Clinical development of imatinib in CML established continuous target inhibition as a paradigm for successful tyrosine kinase inhibitor (TKI) therapy. However, recent reports suggested that transient potent target inhibition of BCR-ABL by high-dose TKI (HD-TKI) pulse-exposure is sufficient to irreversibly commit cells to apoptosis. Here, we report a novel mechanism of prolonged intracellular TK...

Mind wandering (MW) can be persistent and therefore has been included in the repetitive thinking conceptualization. In line with a dimensional view of psychopathology, we hypothesized the existence of a MW-Perseverative Cognition (PC) continuum, where the latter is characterized by a rigid and defensive pattern with attentional, behavioral, affective, and autonomic perseverative manifestations....

We present a conceptual model for building hyperstories. Hyperstories are the hypermedia version of literary stories. The model combines static and dynamic aspects of a computer environment such as a nested context, allowing navigation through a virtual world. The flexibility of the model supports things such as the existence of objects to be acted on by the learner, autonomous objects or chara...

Body Dysmorphic Disorder (BDD) is a distressing and disabling body image disorder that involves excessive preoccupation with physical appearance in a normal appearing person. Persons with BDD exhibit fears of being noticed, feelings of shame and embarrassment, thought processes that can range from repetitive thinking to delusions, avoidance of social situations and exposure of physical appearan...

the idea is growing among educators that thinking skill needs to be given a direct attention. on one hand, critical thinking is supposed to broaden students’ thinking in all regards (schafersman, 1991); and on the other hand learners’ attitudes towards the second language can affect both their performance in the class and their final accomplishment. to this end, the present study started with t...

Finding repetitive subsequences in genome is a challengeable problem in bioinformatics research area. A lot of approaches have been proposed to solve the problem, which could be divided to library base and de novo methods. The library base methods use predetermined repetitive genome’s subsequences, where library-less methods attempt to discover repetitive subsequences by analytical approach...

finding repetitive subsequences in genome is a challengeable problem in bioinformatics research area. a lot of approaches have been proposed to solve the problem, which could be divided to library base and de novo methods. the library base methods use predetermined repetitive genome’s subsequences, where library-less methods attempt to discover repetitive subsequences by analytical approaches. ...