Background. Tablets are still the most preferred means of drug delivery. The search for new and improved direct compression tablet excipients is an area research focus. This because method overcomes drawbacks granulation methods production. It exempts several treatment steps associated with methods. requirements powders to be directly compressible include flowability, low friction tendency, com...

Zanthoxylum bungeanum is a characteristic spice in culinary culture. This article focuses on the lack of intrinsic and contact parameters for studies discrete element tribute pepper from Hanyuan. to provide support mechanized harvesting bungeanum. The EDEM software was used establish model granules. granules, such as Three-dimensional dimension, density, Poisson’s ratio, elastic modulus, were m...

Objective The construction method of the discrete element model and setting simulation parameters in strip- blade-shaped sugarcane leaf are unclear. model’s accuracy greatly influences dynamic response characteristics between particles, it is necessary to improve through parameter calibration. Method optimized calibrated based on surface methodology (RSM) with physical angle repose as value. Fi...

The determination of the engineering properties cashew nut is essential as basis for design and development appropriate optimum post-harvest handling processing machinery. present study examined physical, mechanical colour nuts (n = 100) at a moisture content 7.63% (wet basis) derived from Central Java, Indonesia. main characteristics included length, width, thickness, mass, volume, density. de...

Large landslides exhibit surprisingly long runout distances compared to a rigid body sliding from the same slope, and the mechanism of this phenomena has been studied for decades. This paper shows that the observed long runouts can be explained quite simply via a granular pile flowing downhill, while collapsing and spreading, without the need for frictional weakening that has traditionally been...

In order to improve the calculation efficiency of a discrete element EDEM (Discrete Element Method) numerical simulation software for micron particles, particle model is linearly enlarged. At same time, parameters amplified particles were calibrated according Hertz-Mindlin with JKR (Johnson-Kendall-Roberts) contact make have flow characteristics as actual particles. Actual tests utilized gather...

In the present study, Chitosan microspheres containing Trospium chloride were prepared by coacervation phase separation method and characterized by optical microscopy and scanning electron microscopy. The microspheres were analyzed for drug entrapment, bulk density, angle of repose, particle size and In-vitro release pattern. The effect of process variables on microsphere size was studied and b...

Tizanidine HCl is a centrally acting α-2 adrenergic agonist muscle relaxant. It is slightly bitter in taste. In the present study an attempt has been made to prepare bitterless fast dissolving tablet of Tizanidine Hydrochloride using Eudragit E 100 as a taste masking agent. Mass extrusion was the technique used for preparing taste masked granules. The tablet was prepared with three super disint...