BACKGROUND Several clinical reports have documented a beneficial effect of the addition of a low dose of risperidone to the ongoing treatment with antidepressants, in particular selective serotonin reuptake inhibitors, in the treatment of drug resistant depression. The aim of our study was to understand the mechanism of the clinical efficacy of a combination of fluoxetine (FLU) and risperidone ...

Hypertension with high homocysteine (HHcy) (H-type hypertension) and C reactive protein (CRP) can increase the incidence of ischemic stroke. However, it is not clear whether recurrent ischemic stroke (RIS) is related to H-type hypertension and CRP. The present study investigated the correlation of H-type hypertension and CRP level with RIS. Totally, 987 consecutive patients with acute ischemic ...

Meiosis is the process by which diploid cells undergo DNA synthesis, homologous recombination and pairing, followed by the reductional division then the equational division. I present work in this PhD thesis which furthers the understanding of the coordination of the initiation of meiotic recombination and the reductional division. Ten genes are required to initiate recombination in Saccharomyc...

S U M M A R Y I n order to understand the underlying physics of distributed seismicity better we have considered a 2-D array of slider blocks connected by springs and interacting via static friction with a surface. There is no driving plate in this model. The time evolution of the system is found from numerical simulations in a cellular automata formulation. Energy is conserved and is the singl...

Continental intraplate seismicity seems often episodic, clustered, and migrating. The observed seismicity shows both spatial clustering in seismic zones and scattering across large plate interiors, temporal clustering followed by long periods of quiescence, and migration of seismicity from one seismic zone to another. Here, we explore the complex spatiotemporal patterns of intraplate seismicity...

The development of most unconventional oil and gas resources relies upon subsurface injection of very large volumes of fluids, which can induce earthquakes by activating slip on a nearby fault. During the last 5 years, accelerated oilfield fluid injection has led to a sharp increase in the rate of earthquakes in some parts of North America. In the central United States, most induced seismicity ...

BACKGROUND The pathogenesis of radiation-induced sarcomas (RISs) is not well known. In RIS, TP53 mutations are frequent, but little is known about Mdm2-p53 interaction, which is a recent therapeutic target of sarcomas. METHODS We studied the immunohistochemical expression of Mdm2 and p53 of 8 RISs. The intervals between radiation therapy and diagnosis of secondary sarcomas ranged from 3 to 17...

The concept of background seismicity is strictly related to the identification of spontaneous and triggered earthquakes. The definition of foreshocks, main shocks and aftershocks is currently based on procedures depending on parameters whose values are notoriously assumed by subjective criteria. We propose a method for recognizing the background and the induced seismicity statistically. Rather ...

Historically, seismicity documented in the Western Canada Sedimentary Basin has been relatively quiescent and earthquakes are usually restricted to the foreland belt of the Rocky Mountains. However, exceptional clusters of events, which have remained active for decades, are recognized in Alberta. In this study we investigate the seismicity in this region using data obtained from recently establ...

The recent evolution of induced seismicity in Central United States calls for exhaustive catalogs to improve seismic hazard assessment. Over the last decades, the volume of seismic data has increased exponentially, creating a need for efficient algorithms to reliably detect and locate earthquakes. Today's most elaborate methods scan through the plethora of continuous seismic records, searching ...