Since the introduction in the 1940s of antibiotics as drugs against bacterial infections in human and then veterinary medicine, two major events have caused a shift in the antibiotherapy era: (1) the emergence of resistant bacteria and (2) the awareness of the limits of new drug development. It rapidly became urgent to set up measures in order to evaluate the importance of resistant bacteria an...

The prevalence of antibiotic-resistant bacteria such as methicillin-resistant Staphylococcus aureus is rapidly increasing in healthcare facilities and spreading to the community. Methicillin-resistant S. aureus colonize the skin and open wounds and can interfere with wound healing. Recent studies have shown that ultraviolet light C can kill antibiotic-resistant strains of bacteria such as methi...

The increasing threat of pathogen resistance to antibiotics requires the development of novel antimicrobial strategies. Here we present a proof of concept for a genetic strategy that aims to sensitize bacteria to antibiotics and selectively kill antibiotic-resistant bacteria. We use temperate phages to deliver a functional clustered regularly interspaced short palindromic repeats (CRISPR)-CRISP...

objective: escherichia coli is the most prevalent etiologic agent of urinary tract infections which is the cause of about 80% of cases. enzymatic inactivation of aminoglycosides by aminoglycoside-modifying enzymes is the main mechanism of resistance to these antibiotics in escherichia coli. the aim of this study was the detection of aac(3)-iia gene among aminoglycoside resistant clinical isolat...

The untreated surface water for drinking and domestic use is an alarming situation to public health especially in prevalence of antibiotics resistant bacteria. This investigation aimed to isolate and identify the antibiotic resistance bacteria in underground water samples in district Dera Ismail Khan, Pakistan. The underground water samples were collected from four different places using hand p...

Abstract Cadmium-resistant bacteria that are used to remove cadmium (Cd) becoming increasingly of the most important and hygienic method. Resistant mechanisms involved in different ways, some them which can be removal techniques based on their molecular minimum inhibitory concentration (MIC). This review summarises recent improvements understanding by either intrinsically resistant or acquire r...

Efficacy of Amikacin and Imipenem Against Multi-Drug Resistant Gram-Negative Bacteria Isolated from Wound Infections, Egypt

The discovery of antibiotics represented a turning point in human history. However, by the late 1950s infections that were difficult to treat, involving resistant bacteria, were being reported. Nowadays, multiresistant strains have become a major concern for public and animal health. Antimicrobial resistance is a complex issue, linked to the ability of bacteria to adapt quickly to their environ...

Antimicrobial-resistant bacteria are an emerging problem globally and are associated with increased patient morbidity and mortality. Within hospitals, antibiotic resistant bacteria continue to increase in incidence. As evidenced by the Centers for Disease Control and Prevention National Healthcare Safety Network collection of data across a large number of hospitals, resistance rates for vancomy...