نتایج جستجو برای: respectively three different genotypic variants including aa
تعداد نتایج: 3886708 فیلتر نتایج به سال:
In this paper, we propose a novel mixed-effects model for longitudinal changes of systolic blood pressure (SBP) over time that can estimate the joint effect of multiple sequence variants on SBP after accounting for familial correlation and the time dependencies within individuals. First we carried out agenome-wide association study (GWAS) using chromosome 3 single-nucleotide polymorphisms(SNPs)...
Genetic variants in hormone receptor genes may be crucial predisposing factors for breast cancer, and microsatellites in the estrogen receptor (ESR1, ESR2) and androgen receptor (AR) genes have been suggested to play a role. We studied 258 African-American (AA) women with breast cancer and 259 hospital-based controls, as well as 349 Nigerian (NG) female breast cancer patients and 296 community ...
BACKGROUND Continuous population aging has raised international policy interest in promoting active aging (AA). AA theoretical models have been defined from a biomedical or a psychosocial perspective. These models may be expanded including components suggested by lay individuals. This paper aims to study the correlates of AA in three European countries, namely, Spain, Poland, and Finland using ...
Recently an association was demonstrated between the single nucleotide polymorphism (SNP), rs9939609, within the FTO locus and obesity as a consequence of a genome wide association (GWA) study of type 2 diabetes in adults. We examined the effects of two perfect surrogates for this SNP plus 11 other SNPs at this locus with respect to our childhood obesity cohort, consisting of both Caucasians an...
چکیده معضل چاقی به عنوان عارضه ای جدی برای زندگی بی تحرک و ماشینی، مورد توجه اغلب مراکز بهداشتی و درمانی دنیا قرار گرفته است. چاقی عامل زمینه ساز و در واقع عامل خطری برای بروز بیماری های قلبی - عروقی است که عموماً با کاهش طول عمر مورد انتظار و افزایش بیماری همراه است. هدف پژوهش حاضر تأثیر 12 هفته تمرینات ویبریشن کل بدن، تمرینات هوازی و تمرینات ترکیبی( هوازی و ویبریشن کل بدن) بر ترکیب بدنی زنان ...
Recombination and reassortment of viral genomes are major processes contributing to the creation of new, emerging viruses. These processes are especially significant in long-term persistent infections where multiple viral genotypes co-replicate in a single host, generating abundant genotypic variants, some of which may possess novel host-colonizing and pathogenicity traits. In some plants, succ...
Background: Breast cancer is the first leading cause of cancer-related death in women. Pesticides which are excessively used in northern Iran are one of the most important risk factors for breast cancer incidence. The cytochrome P450 1A1 (cyp1A1) is a key enzyme in xenobiotics metabolism and SNPs of its coding gene has been verified to be important in cancer susceptibility. The aim of thi...
BACKGROUND Parkinson's disease (PD), the second most common neurodegenerative disease, is characterized by loss of dopaminergic neurons in the substantia nigra. The clinical manifestations of PD encompass a variety of motor and non-motor symptoms. Mutations in the F-box protein 7 gene (FBXO7) have been identified to cause Parkinsonian-pyramidal syndrome, an autosomal recessive form of Parkinson...
The objective was to evaluate the effect of beta-lactoglobulin (beta-lg) polymorphism and seasonality on milk composition (fat, lactose, total solids, milk urea nitrogen, total protein, true protein, casein and somatic cell counts) of Holstein and Girolando cows. Milk and blood samples from 278 Holsteins cows and 156 Girolando cows were taken during two dry seasons and two rainy seasons, for mi...
There is increasing evidence that populations of microparasites vary genotypically at a variety of spatial scales, including within host individuals. Understanding this fine-scale structuring of microparasite populations requires descriptions of the relative fitness of individual genotypes isolated from natural mixed infections. Here we examine whether differences between virus genotypes isolat...
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