Introduction: Restless leg syndrome (RLS) is a sensory-motor disorder characterized by uncontrollable urges to move the legs, causing chronic sleep disturbances. Brain iron deficiency has been considered as an important contributing factor to RLS [1-2]. In this study, we applied voxel-based relaxometry (VBR) for in vivo iron measurement and voxel-based morphometry (VBM) for morphological study ...

The restless legs syndrome is a neurological disorder characterised by the urge to move the extremities associated with paraesthesias, which are partially or totally relieved by movement, a worsening of symptoms at rest and in the evening or at night and, as a consequence, sleep disturbances. Restless legs syndrome is common and affects 1-10% of the population. The aetiology of restless legs sy...

Introduction: Restless leg syndrome (RLS) is a sensory-motor disorder causing chronic sleep disturbances. Currently, neuroradiological investigations such as functional MRI, voxel-based relaxometry (VBR) as well as nuclear medicine have revealed a widespread pattern of pathological changes involving cerebra, cerebella and brain stem [1-3]. Thus, underlying mechanism of RLS is not well-understoo...