Time-restricted feeding (TRF) can reduce adiposity and lessen the co-morbidities of obesity. Mice consuming obesogenic high-fat (HF) diets develop insulin resistance hepatic steatosis, but have elevated indices long-chain polyunsaturated fatty acids (LCPUFA) that may be beneficial. While TRF impacts lipid metabolism, scant data exist regarding impact upon lipidomic composition tissues. We (1) t...

Abstract Background The circadian clock is a time keeping mechanism that drives daily rhythms in the body, including behavior and gastrointestinal digestion, inflammation, metabolism. These are endogenous to cells, they must adjust themselves cyclic environmental cues like feeding schedules light dark cycles. However, when cyclical environment chrono-disrupted (ex. shiftwork jetlag), temporal o...