AIMS To report observations relating to the clinical recognition and possible basis of reticular pseudodrusen (RPD). METHODS This retrospective study reports the evolution of RPD in 166 patients who had follow-up of over 1 year using multiple imaging techniques. Mean age when first seen was 73.3 years and the mean period of observation was 4.9 years (range 1-18 years). Associated macular chan...

The patient, a 7-year-old boy, was first seen at the Western Ophthalmic Hospital after a school medical examination showed he had poor visual acuity. He had no previous history of any systemic or ocular illnesses. His parents and grandparents were unrelated. The best corrected visual acuity was 6/iz with +2 75 D cyl., axis I05' in the right eye and 6/9 with + Z5o D cyl. axis 800 in the left eye...

Nowadays, mechanical designers and engineers of elastic structures at ultra-small scales face an interesting challenge; traditional flexures with several components, mechanical joints/ welds and linkages are almost impossible to manufacture with existing microsystem fabrica‐ tion technologies. Therefore, the majority of mechanical components, elements and building blocks are based on micro/nano...

Age-dependent structural changes in brainstem reticular formation were studied. The significant decrease of mean number of neurons in reticular formation was revealed with age increase. The loss of neurons at maximal level was revealed in patients aged 70 years or over. The loss of neurons may result in constant significant damage to functions of reticular formation and may underlie the dysregu...

Acetylcholine (ACh) regulates arousal and the present study was designed to provide insight into the neurochemical mechanisms modulating ACh release in the pontine reticular formation. Nitric oxide-releasing beads microinjected into the pontine reticular formation of C57BL/6J (B6) mouse caused a significant (p<0.0001) increase in ACh release. Microdialysis delivery of the nitric oxide donor NOC...