PURPOSE To investigate the role of β1-adrenergic receptors on insulin like growth factor (IGF)-1 receptor signaling and apoptosis in the retina using β1-adrenergic receptor knockout (KO) mice. METHODS Western blotting and enzyme-linked immunosorbent assay analyses were done on whole retinal lysates from β1-adrenergic receptor KO mice and wild-type littermates. In addition, vascular analyses o...

The retinal vasculature provides a unique window to assess vascular health noninvasively and directly in vivo. Advances in fundus photography and retinal image analysis techniques have enabled the objective and accurate assessment of quantitative retinal vascular caliber measurement. Over the last decade, large population-based studies have shown that retinal vascular calibers are associated wi...

An increasing number of patients with diabetes suffer from vision-threatening diabetic retinopathy (DR), i.e., proliferative diabetic retinopathy (PDR) and diabetic macular edema (DME), worldwide (1). Vascular endothelial growth factor (VEGF) plays a key role in the angiogenic responses in PDR, and the development of anti-VEGF therapy has reduced the burdens of PDR patients (2,3). Retinal vascu...

Using polymerase chain reaction, we detected the varicella-zoster virus genome in the vitreous humor of two patients with clinically diagnosed acute retinal necrosis. One of the two cases was thought to be caused by infection with a varicella-zoster virus lacking a PstI cleavage site. We could not find any clinical differences between the two substrains. The presence of a PstI cleavage site on ...

Newly Recognized Serous Macular Detachment in Retinal Vascular Disease Serous macular detachment has only recently been recognized to occur in a significant number of eyes with retinal vascular leakage, including diabetic macular edema,1,2 branch retinal vein occlusion,3–5 central retinal vein occlusion (CRVO),6 and hypotony maculopathy.7 These serous retinal detachments associated with retinal...

Dear Editor: Acquired Toxoplasma gondii ocular infection usually presents with necrotizing retinochoroiditis with dense vitritis and vasculitis. Atypical disease has been observed in im-munocompromised states such as malignancy and AIDS 1 or after iatrogenic systemic 2 or local 3 immunosuppression. Intravitreal triamcinolone acetonide (TA) is used frequently by ophthalmologists for conditions l...

Optical coherence tomography angiography (OCT-A) is a recently established noninvasive technology for evaluation of the retinal and choroidal vasculature. The literature regarding the findings in choroidal nevi is scarce. We report the OCT-A findings associated with two different variants. Subject one had decreased vascular flow signal in the choroidal, choriocapillaris, deep retinal, and super...

1Department of Ophthalmology, Valiaser Hospital; 2Nursing College, Birjand Medical University, Birjand, Islamic Republic of Iran. 3Department of Ophthalmology, Mashhad University of Medical Science, Mashhad, Islamic Republic of Iran. Received: 09/05/03; accepted: 20/10/03 ABSTRACT To investigate the possible relationship between hyperhomocysteinaemia and retinal vascular occlusion, we measured ...

This study has investigated the association between retinal vascular parameters with type II diabetes in Indian population with no observable diabetic retinopathy. It has introduced two new retinal vascular parameters: total number of branching angles (TBA) and average acute branching angles (ABA) as potential biomarkers of diabetes in an explanatory model. A total number of 180 retinal images ...

In the present study, 110 eyes of 81 patients with uveitis who underwent intravitreal dexamethasone implant (IDI) injection and had a follow‑up at least 6 months between January, 2012 September, 2022, were retrospectively analyzed. A total 298 IDI injections administered (mean, 2.71±2.37; range, 1‑12). The mean age was 49.44±16.67 years (range, 15‑86 years). time after first 34.31±26.53 6‑115 m...