The retinoblastoma is the most frequent malign tumor of the children, starting with the maximum frequency between the ages of one to three years. It is part of the categories of rare diseases, whose frequency is estimated at 1:15.000-1:20.000 newborn babies. It is a tumor of the neuroblast-type placed at the retina level. The retinoblastoma can be unifocal, when a single tumor is present, or mu...

PURPOSE To identify in human retinoblastoma and normal retinal tissue the type of cadherin, its relationship with cytoplasmic catenins, and its participation in invasion. METHODS The cadherin/catenin complex was characterized in surgical retinoblastoma specimens from five patients and human retinas from four donor eyes by immunocytochemistry, flow cytometry, and coimmunoprecipitation with ant...

4-Hydroxy-3-methoxymandelic acid (HMMA) concentrations in aqueous humour, urine, and serum were simultaneously estimated to determine if these levels were raised in cases of retinoblastoma. The catecholamine content of aqueous humour was significantly higher than that of urine and serum, but as there was no significant difference in the HMMA concentration in retinoblastoma and other non-maligna...

An excess of cancer deaths was found in grandparents of 308 children with retinoblastoma. This excess was found in all types of retinoblastoma, unilateral and bilateral, sporadic and familial. We postulated that the excess could be the result of a factor of susceptibility to cancer, different from the retinoblastoma gene, which would increase the mutation rate in retinal and germ cells as well ...

PURPOSE Arsenic trioxide (ATO) targets multiple pathways in malignant cells, resulting in the promotion of differentiation or in the induction of apoptosis. The antitumor activity of ATO on retinoblastoma was investigated. METHODS Human retinoblastoma cells were incubated with various ATO concentrations. The antiproliferative effect of ATO was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-dip...

OBJECTIVE To investigate the compliance and non-compliance of retinoblastoma patients/siblings with their appointments at the Retinoblastoma Clinic in the Pediatric Division of a tertiary eye care center, and to evaluate the contributing factors. METHODS This descriptive type of case series was conducted between May 1999 and May 2002 at the Retinoblastoma Clinic of King Khaled Eye Specialist ...

BACKGROUND Retinoblastoma is the most common childhood tumor of the eye, arising from cells that are defective in both copies of the retinoblastoma susceptibility gene (RB1). Most retinoblastoma tumor cells eventually undergo programmed cell death (i.e., apoptosis); however, some cells can acquire the ability to metastasize and become immortal. Transfection of immortal retinoblastoma cells with...

Surface and cytoplasmic antigens in retinoblastoma were examined by antisera prepared against two tissue-cultured retinoblastoma cell lines. In addition, several other antisera, including anti-rhodopsin, anti-rod outer segment, anti-large-molecular-weight protein, anti-S, and anti-P antigen, were also utilized in a complement-dependent cytotoxicity assay in order to explore the tumor cell surfa...

A 24-year-old black man was found to have bilateral, spontaneously regressed retinoblastoma that had previously been misdiagnosed as post-traumatic chorioretinal scarring. His son and half-brother both had bilateral viable retinoblastoma. The ophthalmoscopic and fluorescein angiographic features of this patient's fundus lesions included a calcified, whitish mass located centrally in one of the ...

We report of a young African child with giant retinoblastoma originating from the left orbital space. The mother and Cameroon seeking medical support at Department Pediatrics. To date arrival, extensive tumor was exulcerating not curable. Only palliative possible.