OBJECTIVE To retrospectively survey the most frequent complications from medial opening wedge high-tibial osteotomy. This procedure is becoming increasingly important in treating knee arthrosis, as one of the options for young and active patients. Despite satisfactory results and its benefits, it is not a complication-free procedure. METHODS All cases of medial opening wedge high-tibial osteo...

The novel biological agent recombinant human thrombomodulin (rhTM) has been used clinically in Japan to treat disseminated intravascular coagulation (DIC) since 2008. Previous studies have shown the efficacy of rhTM versus heparin therapy or non-rhTM therapy. We retrospectively evaluated and compared the efficacies of rhTM and gabexate mesilate (GM) in patients diagnosed with sepsis-induced DIC...

BACKGROUND/AIMS No previous studies have explored the relationship between physical activity (PA) and executive dysfunction. METHODS We retrospectively evaluated the PA for 590 older participants in the Kurihara Project; 221 participants had a Clinical Dementia Rating (CDR) of 0 (healthy), 295 CDR 0.5 (very mild dementia), and 74 CDR 1+ (dementia). RESULTS In the complicated task, whether t...

BACKGROUND Recent molecular characterization of colorectal tumors has identified several molecular alterations of interest that are considered targetable in metastatic colorectal cancer (mCRC). METHODS We conducted a single-institution, retrospective study based on comprehensive genomic profiling of tumors from 138 patients with mCRC using next-generation sequencing (NGS) via FoundationOne. ...

BACKGROUND & AIMS Hepatocellular Carcinoma (HCC) is the sixth most common malignancy and the third most common cause of cancer mortality worldwide. We aimed to assess the effect of novel treatment options on the survival of HCC patients. METHODS This retrospective study included all HCC patients diagnosed between 2000 and 2013 referred to the Davidoff center and treated by a multidisciplinary...

OBJECTIVE Investigate the expression and significance of eosinophils in brucellosis. METHODS Retrospective analysis of clinical data for 151 brucellosis patients (BR group), complete blood count and blood bacterial culture etc.; in addition, 150 general bacterial infection patients (BI group) and 135 persons in healthy physical condition upon testing (NC group) are selected respectively as th...

STUDY DESIGN Retrospective study. OBJECTIVE Symptomatic scoliosis can be a source of severe pain and disability. When nonoperative treatments fail, spine fusion is considered as an effective procedure in scoliosis management. The purpose of this study was to evaluate the trends of patients with scoliosis undergoing posterior long segment fusion (PLSF) with and without recombinant human bone m...

Pharmacoeconomic analyses can be conducted within the context of clinical studies or by using retrospective databases. Randomized clinical trials (RCTs) and observational studies, specifically retrospective database analyses, answer different questions. For example, most RCTs are designed to measure efficacy, not effectiveness. Existing databases can provide effectiveness and “real-world” data....

Background & Aim: Hypertension is an incurable disease which has become a common major risk factor for many cardiovascular diseases worldwide. Besides increasing the risk of heart diseases and stroke, hypertension can also lead to other health conditions such as renal disease and diabetes. The prolong use of orthodox antihypertensive are usually associated with many side effect...

Until recently, most published studies on amblyopia treatment were retrospective reviews of large numbers of patients. Many of these studies reported excellent results with patching for amblyopia. However, there are problems with applying data from such studies to clinical practice. For example, many patients in these retrospective studies were lost to follow-up and therefore excluded from the ...