Objective: To investigate urinary fractions of free and peptide forms of collagen crosslinks in patients with rheumatoid arthritis (n=50), osteoarthrosis (n=38), psoriatic arthritis (n=38) and in healthy volunteers (33 adults, 17 children). Methods: Pyridinoline (PYD) and deoxypyridinoline (DPD) were measured by high performance liquid chromatography. Results: In rheumatoid arthritis (RA) all f...

The advent of monoclonal antibodies to Tumor necrosis factor-α (TNF), has revolutionized the treatment in rheumatoid arthritis (RA). These agents have proved to be highly efficacious, making remission an achievable goal in RA. Golimumab is a human monoclonal antibody to TNF, which is approved by the US FDA for the treatment of RA, psoriatic arthritis and ankylosing spondylitis since April 2009....

180 Canadian Family Physician • Le Médecin de famille canadien d VOL 52: FEBRUARY • FÉVRIER 2006 I is important for family physicians to understand the role of rheumatoid factor (RF) in management of patients with rheumatoid arthritis (RA). Rheumatoid factors are antibodies that recognize the Fc portion of IgG molecules as their antigens; RFs can be of any immunoglobulin isotype (IgM, IgG, IgE)...

OBJECTIVE To investigate urinary fractions of free and peptide forms of collagen crosslinks in patients with rheumatoid arthritis (n=50), osteoarthrosis (n=38), psoriatic arthritis (n=38) and in healthy volunteers (33 adults, 17 children). METHODS Pyridinoline (PYD) and deoxypyridinoline (DPD) were measured by high performance liquid chromatography. RESULTS In rheumatoid arthritis (RA) all ...

Considerable emphasis is currently being placed on the immunogenetics of rheumatoid arthritis (RA). The observation that inherited factors are important in RA is by no means new, however. As far back as 1806 William Heberden in discussing 'chronical rheumatism' asked, 'Is this not in some degree hereditary?'.' The first published attempt to answer this question was by Kroner in 1928,' who repor...

background: rheumatoid arthritis (ra) is a chronic, systemic, inflammatory disease with autoimmune etiology, characterized by synovial inflammation and destruction of joint cartilage and bone. there are controversial data about the profile of interleukin-17 (il-17a), interleukin-4 (il-4), and interferon-gamma (infî³), indicating in some studies the key role of il-17, while in others the th1 cyt...

Background: Rheumatoid arthritis (RA) is an autoimmune disorder affecting nearly 1% of adult population. First-line therapies include disease-modifying antirheumatic drugs, but creno-balneotherapy is often prescribed in rheumatic disorders and RA is no exception. Objectives: To know the efficacy of creno-balneotherapy in RA. Methods: A Medline based search was made using MeSH terms “balneology”...

s accepted to national meetings: 1. Yoshida K, Campbell PL, Amin MA, Koch AE, Fox DA, Ruth JH: Citrullination of ENA78/CXCL5 changes its receptor affinity from CXCR2 to CXCR1 and induces monocyte migration. Arthritis Rheum. 65 S10:327, 2013. 2. Edhayan G, Ha CM , Ohara RA, Isozaki T, Amin MA, Arbab AS, Tsou PS, Campbell PL, Schiopu E, Khanna D, Morgan R, Friday SC, Fox DA, Ruth JH: Inflammatory...

OBJECTIVE To determine the diagnostic and prognostic test qualities of the enzyme linked immunosorbent assays (ELISA) for rheumatoid factor isotypes in rheumatoid arthritis (RA), and to compare them with the latex fixation test. METHODS Rheumatoid factor tests were performed in 1988 consecutive new rheumatology outpatients within two months after their first visit to the outpatient clinic of ...

The concurrence of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) has been reported infrequently. Eleven patients are described here with both RA and SLE, in whom the diagnoses were separated by one to 24 years. Because of the difficulty in diagnosing RA occurring subsequent to SLE, only patients with classical RA as their initial diagnosis were included. Further difficulties ...