The renal glomerulus, the site of plasma ultrafiltration, is exposed to mechanical force in vivo arising from capillary blood pressure and fluid flow. Studies of cultured podocytes demonstrate that they respond to stretch by altering the structure of the actin cytoskeleton, but the mechanisms by which physical force triggers this architectural change and the signaling pathways that lead to gene...

Our laboratory has recently demonstrated that insulin induces relaxation of vascular smooth muscle cells (VSMCs) by activating myosin-bound phosphatase (MBP) and by inhibiting Rho kinase (Begum N, Duddy N, Sandu OA, Reinzie J, and Ragolia L. Mol Endocrinol 14: 1365-1376, 2000). In this study, we tested the hypothesis that insulin via the nitric oxide (NO)/cGMP pathway may inactivate Rho, result...

We study the pseudo-differential operator $$\begin{aligned} T_a f\left( x\right) =\int _{\mathbb {R}^n}e^{ix\cdot \xi }a\left( x,\xi \right) \widehat{f}\left( \,\text {d}\xi , \end{aligned}$$where symbol a is in Hörmander class \(S^{m}_{\rho ,1}\) or more generally rough \(L^{\infty }S^{m}_{\rho }\) with \(m\in \mathbb {R}\) and \(\rho \in [0,1]\). It known that \(T_a\) bounded on \(L^1(\mathbb...

Let $X$ be the product of a surface satisfying $b_2=\rho$ and curve over finite field. We study strong form integral Tate conjecture for $1$-cycles on $X$. generalize give unconditional proofs several results our previous paper with J.-L. Colliot-Th\'el\`ene.

We discuss about the generalized $F$-contraction mappings in partially ordered metric spaces. For this, we first introduce the notion of ordered weakly $F$-contraction mapping. We also present some fixed point results about this type of mapping in partially ordered metric spaces. Next, we introduce the notion of $acute{mathrm{C}}$iri$acute{mathrm{c}}$ type generalized ordered weakly $F$-contrac...

We consider a conservation law model of traffic flow, where the velocity each car depends on weighted average density $\rho$ ahead. The averaging kernel is exponential type: $w_\varepsilon (s)=\varepsilon^{-1} e^{-s / \varepsilon}$. For any decreasing function $v$, we prove that, as $\varepsilon \to 0$, limit solutions to nonlocal equation coincides with unique entropy-admissible solution scala...

A mapping j : GF(q) --> GF(q) is called planar if for every nonzero a. E GF(q) the difference mapping D I.a : x I-t j(x + a) j(x) j(a) is a permutation of GF(q). In this note we show that for certain choices of (3, 'Y the mapping j(:z;) = Tl'({3x CJ+1 ) + -fX~ is planar on GF(q~-J).

We apply the method of QCD sum rules to study $s q \bar s q$ tetraquark states with exotic quantum number $J^{PC} = 3^{-+}$, and extract mass lowest-lying state be $2.33^{+0.19}_{-0.16}$ GeV. To construct relevant currents we need explicitly add covariant derivative operator. Our systematical analysis on their interpolating indicates that: a) this well decays into $P$-wave $\rho\phi/\omega\phi$...

This article is part of a Minifocus on Adhesion. For further reading, please see related articles: ‘Cycling around cell–cell adhesion with Rho GTPase regulators’ by Jessica McCormack et al. (J. Cell Sci. 126, 379391). ‘E-cadherin–integrin crosstalk in cancer invasion and metastasis’ by Marta Canel et al. (J. Cell Sci. 126, 393-401). ‘Mechanosensitive systems at the cadherin– F-actin interface’ ...

Rho-kinase is a serine threonine kinase that increases vasomotor tone via its effects on both endothelium and smooth muscle. Rho-kinase inhibition reduces cerebral infarct size in wild type, but not endothelial nitric oxide synthase deficient (eNOS-/-) mice. The mechanism may be related to Rho-kinase activation under hypoxic/ischemic conditions and impaired vasodilation because of downregulatio...