SETTING Cape Town, South Africa. OBJECTIVE To evaluate the performance of a simple, manual, phage-based test for determining rifampicin (RMP) resistance of Mycobacterium tuberculosis directly from smear-positive sputum specimens. DESIGN A comparative study of the performance of the FASTPlaque (phage amplification) technology to determine RMP resistance directly from smear-positive sputum co...

BACKGROUND Low concentrations of anti-tuberculosis drugs are related to drug resistance and treatment failure. OBJECTIVE To determine the prevalence of low plasma concentrations of anti-tuberculosis drugs. METHODS The study was performed among 60 pulmonary tuberculosis (TB) in-patients at a tertiary care university-affiliated hospital in Tehran, Iran. Drug samples were drawn 2 and 6 h post ...

To further the development of a multidrug regimen for treatment of leprosy that is suitable for monthly administration and fully supervisable, the bactericidal activities against Mycobacterium leprae of HMR 3647 (HMR), moxifloxacin (MXFX) and rifapentine (RPT) were measured by the proportional bactericide technique in the mouse footpad system, and compared with those of the established antilepr...

The computing of applications in embedded devices suffers tight constraints on computation and energy resources. Thus, it is important that applications running on these resource-constrained devices are aware of the energy constraint and are able to execute efficiently. The existing execution time and energy profiling tools could help developers to identify the bottlenecks of applications. Howe...

The neurotrophic role of acetylcholine (ACh) in the denervation-dependent decline of muscle resting membrane potential (RMP) was evaluated. Freshly dissected rat hemidiaphragms with short or long (2 cm) nerve stumps attached ("-N" and "+N" preparations, respectively) were incubated in organ culture in the presence or absence of the nicotinic blockers, alpha-bungarotoxin (alpha-BTX) or d-tubocur...

In this article, we propose a new algorithm for the resolution of mixed integer bi-level linear problem (MIBLP). The algorithm is based on the decomposition of the initial problem into the restricted master problem (RMP) and a series of problems named slave problems (SP). The proposed approach is based on Benders decomposition method where in each iteration a set of variables are fixed which ar...

L Li in nk ki in ng g O OI II I a an nd d R RM MP P* *I In nf fo o D Da at ta a: : D Do oe es s e ev ve er ry yd da ay y s sa af fe et ty y p pr re ev ve en nt t c ca at ta as st tr ro op ph hi ic c l lo os ss s? ? Abstract We link the RMP database of accident histories collected for the period 1996-2000 under section 112(r) of the Clean Air Act Amendments and OSHA reported Occupational Illness...

Rifampin is a major drug used to treat leprosy and tuberculosis. The rifampin resistance of Mycobacterium leprae and Mycobacterium tuberculosis results from a mutation in the rpoB gene, encoding the β subunit of RNA polymerase. A method for the molecular determination of rifampin resistance in these two mycobacteria would be clinically valuable, but the relationship between the mutations and su...

the effects of range management plans (rmp) on soil and vegetationcharacteristics were studied in eshtehard rangelands at alborz province. the parameters ofyield, canopy cover, range condition and trend, bulk density, organic matter (om%),nitrogen (n), phosphorous (p) and potassium (k) were estimated on soil samples in sitesof ghenzel cheshmeh as rmp and sanctum of rahmanyeh village. the data w...

Eight weeks of treatment with rifampin-streptomycin sterilizes Mycobacterium ulcerans infection in mice. Because the bactericidal activity against M. ulcerans of the combination rifampin-moxifloxacin, rifampin-clarithromycin, or moxifloxacin-clarithromycin was similar to that of rifampin-streptomycin, these combinations might be considered as alternative, orally administered combined regimens f...