The insulin-like growth factor II (IGF2) gene is exclusively silent at the maternal allele in the mouse as well as in normal human tissues and is expressed at a high level in rhabdomyosarcoma (RMS). We report here that the normally imprinted allele of the IGF2 gene is activated in RMS tumors as well as in one RMS cell line. Since overexpression of IGF2 has been shown to be important in the path...

We study the long term evolution of the relationship between the root mean square (rms) variability and flux (the " rms-flux relation ") for the black hole Cygnus X-1 as monitored from 1996 to 2003 with the Rossi X-ray Timing Explorer (RXTE). We confirm earlier results by Uttley & McHardy (2001) of a linear relationship between rms and flux in the hard state on time scales > 5 s reflecting in i...

در این کار پژوهشی، نمونه‌های هیدروکسی اپتایت آلاییده با ناخالصی‌های سریم، گادولونیم و ترکیبی از دو ناخالصی به روش هیدروترمال سنتز شدند. منظور بررسی فازهای بلوری تشکیل یافته هرکدام شده، کد MAUD که یک نرم‌افزار برای تجزیه تحلیل ساختار ماده استفاده پراش بر اساس ریتولد است، شد. پاسخ دزیمتری ترمولومینسانس نمونه‌ها مورد قرار گرفت یافته‌ها نشان داد نمونه‌ ترکیبی، سطح میانی است. مشخص شد افزودن سریم می‌...

Rhabdomyosarcoma (RMS) is the most frequent soft tissue sarcoma in children. Improved treatment strategies have increased overall survival, but the response of approximately one-third of the patients is still poor. To increase the knowledge of RMS pathogenesis, we performed the first full transcriptome analysis of RMS using serial analysis of gene expression (SAGE). With a G-test for the simult...

OBJECTIVE Positive end-expiratory pressure (PEEP) and recruitment maneuvers (RMs) may partially reverse atelectasis and reduce ventilation-associated lung injury. The purposes of this study were to assess a) magnitude and duration of RM effects on arterial oxygenation and on requirements for oxygenation support (Fio2/PEEP) in patients with acute lung injury and acute respiratory distress syndro...

dear editor:   hehua ye and colleagues reported an interesting and rare case of primary conjunctival rhabdomyosarcoma (rms) successfully treated with surgery and chemotherapy in iranian journal of ophthalmology 201123(4):65-68. there are some considerable comments that i would like to point out.   orbital rms is the most common malignant mesenchymal neoplasm of the childhood and may also rarely...

PURPOSE Rhabdomyosarcoma (RMS) is a common pediatric soft-tissue tumor. In this study, we evaluated the efficacy and selectivity of drozitumab, a death receptor DR5-targeted therapeutic antibody, in RMS preclinical models. EXPERIMENTAL DESIGN A panel of 11 RMS cell lines was used for in vitro studies. The molecular marker predictive of response to drozitumab was interrogated. Selected RMS cel...