She had been exposed to strong sunlight through a car windscreen for 2 h on the previous day and also on return to the hospital. The erythema was limited to areas of light exposure with a band of unaffected skin beneath her watch strap ( fig. 2 ). There was no phototoxicity at the covered injection sites. The patient was systemically well but did report passing red-coloured stools. A diagnosis ...

AIM The ultrasonically induced effect of a tumor accumulative derivative of rose bengal (RB) on isolated tumor cells was investigated to clarify whether the RB derivative (RBD) maintains the sonosensitizing ability of RB. MATERIALS AND METHODS Sarcoma 180 cells were suspended in air-saturated phosphate-buffered saline and were exposed to ultrasound in standing wave mode for up to 60 s in the ...

The new concept of Immunogenic Cell Death (ICD), associated with Damage Associated Molecular Patterns (DAMPs) exposure and/or release, is recently becoming very appealing in cancer treatment. In this context, PhotoDynamic Therapy (PDT) can give rise to ICD and to immune response upon dead cells removal. The list of PhotoSensitizers (PSs) able to induce ICD is still short and includes Photofrin,...

Kinesin motor proteins use ATP hydrolysis for transport along microtubules in the cell. We sought to identify small organic ligands to inhibit kinesin's activity. Candidate molecules were identified by computational docking of commercially available compounds using the computer program DOCK. Compounds were docked at either of two sites, and a selection was tested for inhibition of microtubule-s...

A cross-sectional study was conducted in the pastoral region of Afar, in eastern and central Ethiopia, to determine the distribution of brucellosis in small ruminants. Between December 2005 and June 2006, 1,568 serum samples were taken: 563 samples from sheep and 1,005 from goats. One hundred and forty-seven of these (9.4%) tested positive using the Rose Bengal plate test (RBPT), and 76 (4.8%) ...

After oneand two-colour ps-excitation the transient absorption of rose bengal, erythrosin B and eosin Y in the spectral range from 450 to 670 nm was probed using picosecond continuum pulses generated in H2O—D 2 O mixture. Our experiments showed for all dyes a high T1—Tn absorption signal above 590 nm where no ground state absorption occurs. These excited triplet states can be effectively popula...

A cross-sectional survey of the seroprevalence of brucellosis in sheep, goats and cattle in Kosovo was made in January 2001. A total of 12,000 serum samples, from 7941 cattle, 3548 sheep and 511 goats, were screened using the Rose Bengal test. Doubtful and positive results were further tested with competitive and indirect ELISAS. The overall serological prevalences derived from the samples posi...

Many of the core concepts and (especially field-theoretic) tools of statistical mechanics have developed within the context of thermodynamic equilibrium, where state variables are all taken to be charges, meaning that their values are inherently preserved under reversal of the direction of time. A principle concern of nonequilibrium statistical mechanics is to understand the emergence and stabi...

We present a computational study on the electrical bistability behavior of four xanthene derivatives based on sodium fluorescein. Intra- and intermolecular charge transfer parameters are computed and employed to rationalize the efficiencies experimentally determined for resistive memory devices based on these organic materials. Charge injection at the electrode/organic interface in the presence...