Nineteen adults and 9 children who received a unilateral cochlear implant between 2002 and 2007 were included in the study. All subjects were preoperatively diagnosed with significant residual hearing in low frequencies, termed as 'partial deafness', and were implanted according to a 6-step round window surgical technique for partial deafness cochlear implantation. Hearing was preserved to a gr...

Controlled-release carriers for local drug delivery have attracted increasing attention for inner-ear treatment recently. In this paper, flower-shaped bovine serum albumin (FBSA) particles were prepared by a modified desolvation method followed by glutaraldehyde or heat denaturation. The size of the FBSA particles varied from 10 μm to 100 μm, and most were 50-80 μm. Heat-denatured FBSA particle...

Sensorineural hearing loss is the most common type of hearing loss worldwide, yet the underlying cause is typically unknown because the inner ear cannot be biopsied today without destroying hearing, and intracochlear cells have not been imaged with resolution sufficient to establish diagnosis. Intracochlear imaging has been technologically challenging because of the cochlea's small size and enc...

We conducted a retrospective study to evaluate the long-term effectiveness of gentamicin applied directly to the round window membrane via the Silverstein MicroWick system in patients with definite or probable Ménière's disease. The study population was made up of 69 patients who had received 3 drops of gentamicin 10 mg/ml three times daily; the duration of treatment was guided by objective dat...

There are multiple treatment options to consider when managing patients with Menière's disease. When conservative measures fail to control symptoms of Menière's disease, escalation of interventions may be required. Targeted drug delivery to the round window with intratympanic injections allows for local application of high concentrations of medications, largely avoiding systemic side effects. I...

We use random linear network coding (RLNC) based scheme for multipath communication in the presence of lossy links with different delay characteristics to obtain ultra-reliability and low latency. A sliding window version of RLNC is proposed where the coded packets are generated using packets in a window size and are inserted among systematic packets in different paths. The packets are schedule...

The hours of service regulations of the department of transportation severely restrict the set of feasible driver schedules. So much so that establishing whether a sequence of full truckload transportation requests, each with a dispatch window at the origin, can feasibly be executed by a driver is no longer a matter of simple forward simulation. We consider this problem and prove that the feasi...

Purpose – Disasters provide physical, social, economic, political and environmental development windows of opportunity particularly through housing and infrastructure reconstruction. The reconstruction process should not be neglected due to the opportunistic nature of facilitating innovation in development. In this respect, postdisaster ‘infrastructure’ reconstruction plays a critical role in d...

Surgery to correct congenital conductive hearing loss affords an opportunity for the otologic surgeon to drastically alter the patient’s hearing environment and offer a normal level of hearing in lieu of a lifetime of hearing aids. Unfortunately, the spectrum of abnormalities encountered in the congenital middle ear is wide, and the surgeon must be prepared for a variety of tasks. Perhaps the m...