For many years now, identification of native medicinal plants which are effective in improving human health has been the focus of attention by the United Nations World Health Organization. Sambucus nigra is a valuable medicinal plant used for a long time in traditional medicine for prevention and treatment of common diseases such as cold, joint swell, and rheumatic pains. In this research, root...

In the present study, various mixtures of aqueous ethanol and acetone solutions were utilized to extract anthocyanins from eggplant peel by a discontinuous process to obtain a natural red-purple colorant. First, the most appropriate combination for extraction solvent was selected as ethanol 70 wt in water acidified with acetic acid 3 wt, which was determined by analysis of extraction yields and...

This study exploited the application of pulsed electric field (PEF) on recovery polyphenols from aerial parts Sideritis scardica, tepals Crocus sativus, and fruits Vitis vinifera. Short pulses 10 μs in a period 1 ms were applied to plant material, while different intensities, 1.2 2.0 kV/cm tested optimize procedure. The content total polyphenolic profile extracts evaluated. Along with PEF sampl...

Medicinal plants have been used from the beginning of human civilization against various health complications. Dengue virus (DENV) has emerged as one most widespread viruses in tropical and subtropical countries. Yet no clinically approved antiviral drug is available to combat DENV infection. Consequently, search for novel antidengue agents medicinal assumed more insistence than previous days. ...

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the virus that causes 2019 (COVID-19). To date, there has been no proven effective drug for treatment or prevention of COVID-19. A study on developing inhibitors this was performed using molecular dynamics simulation. 3CL-Pro, PL-Pro, Helicase, N, E, and M protein were used as targets. This aimed to determine stability selected pro...

Department of Chemistry and Research Institute of Basic Science, Chonnam National University, Gwangju 500-757, Korea Department of Chemistry, and Research Institute of Life Science, Gyeongsang National University, Chinju 660-701, Korea Department of Chemical Education, and Research Institute of Life Science, Gyeongsang National University, Chinju 660-701, Korea. *E-mail: [email protected] Receiv...

BACKGROUND Advanced glycation end-products (AGEs) play a significant role in the development and progression of vascular complication in diabetes. Anthocyanin has been recently reported to possess antiglycating activity. This study aimed to determine whether a naturally occurring anthocyanin, cyanidin-3-rutinoside (C3R) inhibits methylglyoxal (MG) induced protein glycation and oxidative protein...

MOTIVATION Rhodopsin is a visual pigment present in rod cells of retina. It belongs to GPCR family and involves photoisomerization of 11-cis-retinal to all-trans-retinal isomers, conformational changes in rhodopsin and signal transduction cascade to generate a nerve impulse. This signaling pathway has been targeted to eliminate the effect of a mutation (Gly90→Asp) responsible for abnormal activ...