p 53 T um o r S up p re ss o r Trp53 mouse germline knockout. Trp53−/− homozygous: 100% tumor penetrance at ?4.5 months. Typical tumors: T cell lymphoma (>60%); soft tissue sarcoma (?25%); osteosarcoma, brain tumors, teratoma (together <15%); carcinomas rarely observed. Trp53+/− heterozygous: 50% tumor penetrance at 17 months. Typical tumors: T cell lymphoma (?30%); soft tissue sarcoma (?30%); ...

Although rare, synovial sarcoma is the most common malignant non-rhabdomyosarcomatous soft tissue sarcoma in children and adolescents. Synovial sarcoma typically involves the soft tissues of the extremities, especially near large joints, but it can occur anywhere in the body in locations far from joint spaces. Although this tumor typically affects adults in their fourth decade of life, nearly h...

endometrial stromal sarcoma represents a very rare pathological entity occurring as a malignant disease in women genital sphere, frequently in the age group of 40-50 years. low grade endometrial stromal sarcoma (lgess) is a rare uterine sarcoma constituting 0.2% of all the uterine malignancies with a good prognosis despite a tendency to recur. we report a case of 42 years old woman presented wi...

introduction low-grade endometrial stromal sarcoma (lg-ess) is a malignant intrauterine tumor that rarely presents with distant metastasis. simultaneous lung and cardiac metastases from lg-ess is also an extremely rare event. case presentation a 42-year-old woman presented with dyspnea and exercise intolerance. she had a history of hysterectomy and left salpingoophorectomy. she underwent second...

background: rhabdomyosarcoma is a rare malignant soft tissue sarcoma and the most common sarcoma of childhood. the purpose of this study was to investigate the distribution of age and sex of patients, pathological subtypes and to determine the role of staging and classification of rms on treatment outcome. materials and methods: this retrospective study included patients who diagnosed with rms ...

primary bone tumors are the sixth most common neoplasm occurring in children and constitute approximately 6% of all childhood malignancies with a peak incidence in 15- to 19-year- old individuals. these lesions are the third most common tumors in adolescents and young adults (exceeded only by leukemia and lymphoma) common complaints are intermittent to constant mild to severe pain, constitution...

We describe the case of a 71-year-old man who presented with single painful soft tissue mass right thigh. Following imaging and subsequent excision, histological immunohistochemical assessment tumour was performed, diagnosis epithelioid haemangioendothelioma (EHE) made. EHE is rare translocation-related vascular sarcoma variable clinical behaviour ranging from low grade malignancy ability to re...

we present a case of epitheloid sarcoma that was referred with a 2×3cm ulcerated lesion on the right ankle and edema of the lower leg. foot drop of the right side was present that had caused walking difficulty. after a few months, he developed several sporthricoidal nodular lesions on the medial aspect of right thigh, inguinal lymphadenopathy, weight loss, anorexia and respiratory symptoms. che...

although most breast cancers are adenocarcinomas of the mammary gland, primary breast sarcomas may also arise from mammary gland mesenchymal tissue. sarcomas represent less than 1% of primary breast neoplasms. these tumors are at high risk of recurrence and are known to have poor prognosis. surgical resection is the primary treatment for these lesions and axillary lymph node dissection is not r...

primary myeloid sacrom (ms) is a rare tumor and even more rare in multiple organs with no evidence of bone marrow involvement. this report describes an unusual case of a 19-year-old male presenting scrotal ms with a history of subconjunctival ms, 5 months ago. bone marrow biopsies showed no evidence of acute leukemia. despite radiotherapy for first involvement and chemotherapy for second presen...