Saffron or Crocus sativus L. (C. sativus) has been widely used as a medicinal plant to promote human health, especially in Asia. The main components of saffron are crocin, picrocrocin and safranal. The median lethal doses (LD50) of C. sativus are 200 mg/ml and 20.7 g/kg in vitro and in animal studies, respectively. Saffron has been suggested to be effective in the treatment of a wide range of d...

as an aromatic and colorful plant of substantive taste, saffron (crocus sativus l.) owes such properties of matter to growing class of the secondary metabolites derived from the carotenoids, apocarotenoids. regarding the critical role of micrornas in secondary metabolic synthesis and the limited number of identified mirnas in c. sativus, on the other hand, one may see the point how the characte...

background crocus sativus l. (saffron), which belongs to the iridaceae family, is widely cultivated in iran. cardiovascular effects of saffron has been established in some studies but the effects of chronic administration of saffron (c. sativus) stigma aqueous extract on blood pressure has not been investigated. objectives in this study the effects of saffron (c. sativus) stigma aqueous extract...

Objective: There are different pathophysiological mechanisms for obsessive- compulsive disorder (OCD) as suggested by the serotonergic, dopaminergic, and glutamatergic hypotheses. The present study aimed at comparing the efficacy and safety of saffron (stigma of Crocus sativus) and fluvoxamine in the treatment of mild to moderate obsessive- compulsive disorder. Method: In this study, 50 males a...

Crocetin is an aglycon of carotenoid extracted by saffron stigmas (Crocus sativus L.) and known to have a potent anti-oxidative effect. Amyliod β (Aβ), hallmark of Alzheimer’s disease, is reported to have neurotoxicity partly via oxidative stress. In this study, we investigated the effect of crocetin on hippocampal HT22 cell death induced by Aβ1-42. Furthermore, to clarify the mechanism underly...

in this study, the genetic diversity of 25 iranian saffron genotypes from three species (crocus speciosus, crocus cancellatus and crocus sativus) has been evaluated using 16 morphological traits and rapd marker. c. sativus was different with speciosus in the leaf number per plant, tepal length, flower weight, inflorescence stem height and the stigma length, but had no significant difference wit...

Hydroponics is a promising method for cultivation of saffron ( Crocus sativus ). In this study, corms were sprouted using gradual decrease in air temperature, and they cultivated hydroponically either perlite or volcanic rock 24 weeks. A nutrient solution was supplied an ebb-and-flow system continuous immersion. First blooming observed 29 days after transplantation. Among flowering traits, only...

Context: Saffron, as a medicinal plant, is widely used to treat various diseases, especially among women. Therefore, this study was conducted review the studies on impact of saffron premenstrual syndrome (PMS), labor, childbirth, and menopause. Methods: This systematic review, based PICO process, systematically searched PubMed, Scopus, Cochrane, Embase, Web Science, Science Direct, Google Schol...

The presence and extent of genetic variation in saffron crocus are still debated, as testified by several contradictory articles providing contrasting results about the monomorphism or less of the species. Remarkably, phenotypic variations have been frequently observed in the field, such variations are usually unstable and can change from one growing season to another. Considering that gene exp...