The product of the Brca1 tumor-suppressor gene is involved in multiple aspects of the cellular DNA damage response (DDR), including activation of cell-cycle arrests and DNA double-stranded break (DSB) repair by homologous recombination. Prior reports demonstrated that BRCA1 recruitment to areas of DNA breakage depended on RAP80 and the RNF8/ RNF168 E3 ubiquitin ligases. Here, we extend these fi...

Lung is one of the organs of the rat with a particular abundance of haemagglutinating activity that is inhibited by beta-galactosides. This lectin activity can be attributed to a single protein that has been purified from rat lung; a similar protein has been purified from human lung. The molecular weights and subunit structures were estimated from gel filtration and sodium dodecyl sulphate/poly...

BACKGROUND Helicobacter pylori eradication triple therapy with a combination of lansoprazole, amoxicillin and clarithromycin was approved in Japan in September 2000. AIM To compare the cost-effectiveness of this eradication therapy with conventional histamine-2 receptor antagonist therapy in Japan. METHODS We established two Markov models for gastric and duodenal ulcers. The model design wa...

BACKGROUND Genetic factors in the pathogenesis of cardiomyopathies have received a lot attention during the past two decades. Angiotensin I converting enzyme (ACE) insertion/deletion (I/D) polymorphisms were found to be associated with cardiomyopathies. However, the previous results were inconsistent. The current meta-analysis aims to examine the association of ACE I/D polymorphisms and dilated...

OBJECTIVE To evaluate the association of intrapartum magnesium sulfate for fetal neuroprotection (MgSO4-FN) with the delivery room resuscitation and neonatal outcomes of preterm infants in an era of minimisation of invasive mechanical ventilation. DESIGN Retrospective cohort study. SETTING Neonatal intensive care units in the Canadian Neonatal Network. PATIENTS AND INTERVENTION Preterm in...

Multidrug resistance (MDR) is a common problem in the treatment of childhood rhabdomyosarcoma (RMS). A complete reversal of MDR is currently not possible. The aim of this study was to investigate the role of glutathione-S-transferase (GST) as mechanism of MDR in childhood RMS and to analyze possible reversal strategies. Female athymic mice underwent xenotransplantation with embryonal or alveola...

1. McClelland MT. Paraneoplastic syndromes related to lung cancer. Clin J Oncol Nurs 2010;14:357‐64. 2. Noronha V, Dikshit R, Raut N, Joshi A, Pramesh CS, George K, et al. Epidemiology of lung cancer in India: Focus on the differences between non‐smokers and smokers: A single‐centre experience. Indian J Cancer 2012;49:74‐81. 3. Myers EA, Hardman JM, Worsham GF, Eil C. Adenocarcinoma of the lung...

OBJECTIVE To investigate the dose-response relationship between breastfeeding duration and cognitive development in French preschool children. STUDY DESIGN In the French EDEN Mother-Child Cohort Study, we evaluated language ability with the Communicative Development Inventory (CDI) in 1387 2-year-old children and overall development with the Ages and Stages Questionnaire (ASQ) in 1199 3-year-...

Since the pioneering work of Turing on the formation principles of animal coat patterns [Turing AM (1952) Phil Trans R Soc Lond B 237(641):37-72], such as the stripes of a tiger, great effort has been made to understand and explain various phenomena of self-assembly and pattern formation. Prominent examples are the spontaneous demixing in emulsions, such as mixtures of water and oil [Herzig EM,...

2. Tiebosch ATMG. Frederick PM, van Breda Vriesman PJC, et at. Thinbasement-membrane nephropathy in adults with persistent hematuria. N Engl J Med 1989; 320:14-8. 3. Groggel GC, Adler S, Rennke H, Couser WG, Salant DJ. Role of the terminal complement pathway in experimental membranous nephropathy in the rabbit. J Clin lnvest 1983; 72:1948-57. 4. Rahman MA, Liu CN, Dunn MJ, Emancipator SN. Compl...