Article history: Received October 15, 2011 Accepted 10 March 2012 Available online 14 March 2012 In order to prepare students for the workforce, academic programs incorporate a variety of tools that students are likely to use in their future careers. One of these tools employed by business and technology programs is the integration of live software applications such as SAP through the SAP Unive...

Distributions exhibiting fat tails occur frequently in many different areas of science. A dynamical reason for fat tails can be a socalled superstatistics, where one has a superposition of local Gaussians whose variance fluctuates on a rather large spatio-temporal scale. After briefly reviewing this concept, we explore in more detail a class of superstatistics that hasn’t been subject of many i...

None of the mammalian splicing factors that have been cloned corresponds to the yeast pre-messenger RNA splicing factors, the PRP proteins. Here, a generalizable strategy was used to isolate a complementary DNA encoding the mammalian spliceosome-associated protein (SAP) SAP 62. It is demonstrated that SAP 62 is the likely functional homolog of the yeast PRP11 protein. Both PRP11 and SAP 62 asso...

Intrathecal (IT) substance P-Saporin (SP-SAP), a 33-kDa-targeted neurotoxin, produces selective destruction of superficial neurokinin 1 receptor (NK1r)-bearing cells in the spinal dorsal horn. In rats, SP-SAP prevents the formation of hyperalgesia and can reverse established neuropathic pain behavior in rodents. To determine the safety of this therapeutic modality in a large animal model, beagl...

Cytokinin-like activity in samples of xylem and phloem sap collected from field-grown plants of white lupin (Lupinus albus L.) over a period of 9 to 24 weeks after sowing was measured using the soybean hypocotyl callus bioassay following paper chromatographic separation. The phloem sap was collected from shallow incisions made at the base of the stem, the base of the inflorescence (e.g. stem to...

The sap of Acer mono has been called 'bone-benefit-water' in Korea because of its mineral and sugar content. In particular, the calcium concentration of the sap of A. mono is 37.5 times higher than commercial spring water. In the current study, we examined whether A. mono sap could improve or prevent osteoporosis-like symptoms in a mouse model. Male mice (3 weeks old) were fed a low-calcium die...

It has been reported that matrix metalloproteinase 9 (MMP-9) disrupts basement membrane and increases vascular permeability. MMP-9 therefore might participate in the pathogenesis of severe acute pancreatitis (SAP). Captopril, an angiotensin-converting enzyme inhibitor, could reduce MMP-9 expression. However, the effect of captopril on the outcome of SAP is not ascertained. The aim of this study...

Eldercare professionals engaged in precarious work the Netherlands faced shortages personal protective equipment (PPE), testing, and staffing during COVID-19 pandemic. This qualitative study of health, financial situations, paid unpaid caring responsibilities freelance eldercare workers illustrates how labor market inequalities have been (re)produced exacerbated Freelancers were pushed toward m...

glutathione s-transferases (gsts; ec: 2.5.1.18) are a ubiquitous family of eukaryotic and prokaryotic phase ii metabolic isozymes. genes encoding gstm1 (omim: 138350), and gstt1 (omim: 600436) are members of class mu and theta, respectively. the most common polymorphism in the gstm1 is a deletion of the whole gstm1 gene with a lack of enzyme activity. a homozygous deletion in the gstt1 has also...

Monocyte-derived, fibroblast-like cells called fibrocytes are associated with fibrotic lesions. The plasma protein serum amyloid P component (SAP; also known as pentraxin-2, PTX2) inhibits fibrocyte differentiation in vitro, and injections of SAP inhibit fibrosis in vivo. SAP is a member of the pentraxin family of proteins that includes C-reactive protein (CRP; PTX1) and pentraxin-3 (PTX3). All...