This paper proposes an innovative Mixture Statistical Distribution Based Multiple Component (MSDMC) model for target detection in high spatial resolution Synthetic Aperture Radar (SAR) images. Traditional detection algorithms usually ignore the spatial relationship among the target’s components. In the presented method, however, both the structural information and the statistical distribution a...

A structure-activity relationship (SAR) study was carried out to identify novel, small molecular weight compounds which induce readthrough of premature termination codons. In particular, analogs of RTC13, 1, were evaluated. In addition, hypothesizing that these compounds exhibit their activity by binding to the ribosome, we prepared the hybrid analogs 13 containing pyrimidine bases and these al...

Necrostatin-5 (Nec-5) is a novel potent small-molecule inhibitor of necroptosis structurally distinct from previously described Necrostatin-1 (Nec-1), and therefore, represents a new direction for the inhibition of this cellular caspase-independent necrotic cell death mechanism. Here, we describe a series of structural modifications of Nec-5 and the structure-activity relationship (SAR) of Nec-...

although, coumarins are a group of compounds which are naturally found in some plants, they can be synthetically produced as well. because of their diverse derivatives, origin and properties most of them can be used for medicinal purposes. for example, they can be used against fungal diseases or in studying structure and biological properties of antifungal agents to discover new compounds with ...

Cannabidiol (CBD) exhibits anticonvulsant activity in experimental animals and in man. As part of a structureactivity study, analogs were prepared wherein the terpene unit, the aryl unit, and/or the side chain were modified. Thus, several pinenyl and carenyl derivatives, aryl ethers and acetates, and a variety of 1",1"-dialkylhexyl and 1",1"dialkylheptyl analogs were synthesized. The compounds ...

This study is a new assessment of damaged roads after the Kumamoto earthquake in southern Japan (2016) using remotely sensed synthetic aperture radar (SAR) data, field data and deep learning. Three SAR images from descending orbits Sentinel-1 VV (vertical-vertical) polarizations are considered for radiometric calibration, geocoding interferometric analyses. Field terms IRI (international roughn...